Disease relevance of LMCD1

• Angiographic variables of importance included left ventricular wall motion abnormalities, and left main coronary disease (LMCD) [1].
• Screening programs for late-onset, biotin-responsive, multiple carboxylase deficiency (LMCD) detect colormetrically the presence of biotinidase activity in dried samples of whole-blood spotted on filter-papers as used in the neonatal screening of phenylketonuria [2].
• Three factors appeared to be related to the occurrence of myocardial infarction: left main coronary artery disease (LMCD), (47%, 7/15), increased left ventricular end-diastolic pressure (LVEDP), (27%, 14/52), and cardiopulmonary bypass time more than 60 minutes (24%, 21/88) [3].

High impact information on LMCD1

• The present report of 1484 patients with LMCD in the Coronary Artery Surgery Study (CASS) Registry extends the originally published 5-year surgical and medical group survival analysis to more than 16 years of follow-up and permits analysis of LMCD patient subgroups [4].
• Median survival was also significantly longer in the surgical group stratified by age, sex, anginal class, left ventricular (LV) function, coronary anatomy, and the extent of LMCD [4].
• The predicted LMCD1 protein contains a novel cysteine-rich domain residing in the amino-terminal region and two LIM domains with regular spacing in the carboxy-terminal region [5].
• A new human LIM domain gene LMCD1 was identified from RT-PCR products, and partial sequencing of two expressed sequence tag clones flanking the assembled cDNA contig revealed a 1743-bp full-length cDNA with 1098-bp open reading frame [5].
• Radiation hybrid mapping localized human LMCD1 to the telomeric region of chromosome 3p, and genetic mapping assigned the mouse Lmcd1 locus to the central region of chromosome 6 [5].

Biological context of LMCD1

• Using molecular biology combined with in silico cloning, we have cloned the complete coding sequence of pig LIM and the cysteine-rich domain 1 gene (LMCD1) which encodes a 363 amino acid protein [6].

Associations of LMCD1 with chemical compounds

• Three factors appeared related to the occurrence of MI: 1) abrupt propranolol withdrawal 24 hours prior to surgery (Prop) (32%, 33/103); 2) left main coronary artery disease (LMCD) (37%, 7/19); and 3) cardiopulmonary bypass longer than 60 minutes (CPB) (23%, 30/128) [7].

Analytical, diagnostic and therapeutic context of LMCD1

• BACKGROUND: Left main coronary artery disease (LMCD) is considered a relative contraindication to off-pump coronary artery bypass (OPCAB) grafting [8].

References