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Gene Review

LMCD1  -  LIM and cysteine-rich domains 1

Homo sapiens

Synonyms: Dyxin, LIM and cysteine-rich domains protein 1
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Disease relevance of LMCD1


High impact information on LMCD1

  • The present report of 1484 patients with LMCD in the Coronary Artery Surgery Study (CASS) Registry extends the originally published 5-year surgical and medical group survival analysis to more than 16 years of follow-up and permits analysis of LMCD patient subgroups [4].
  • Median survival was also significantly longer in the surgical group stratified by age, sex, anginal class, left ventricular (LV) function, coronary anatomy, and the extent of LMCD [4].
  • The predicted LMCD1 protein contains a novel cysteine-rich domain residing in the amino-terminal region and two LIM domains with regular spacing in the carboxy-terminal region [5].
  • A new human LIM domain gene LMCD1 was identified from RT-PCR products, and partial sequencing of two expressed sequence tag clones flanking the assembled cDNA contig revealed a 1743-bp full-length cDNA with 1098-bp open reading frame [5].
  • Radiation hybrid mapping localized human LMCD1 to the telomeric region of chromosome 3p, and genetic mapping assigned the mouse Lmcd1 locus to the central region of chromosome 6 [5].

Biological context of LMCD1

  • Using molecular biology combined with in silico cloning, we have cloned the complete coding sequence of pig LIM and the cysteine-rich domain 1 gene (LMCD1) which encodes a 363 amino acid protein [6].

Associations of LMCD1 with chemical compounds

  • Three factors appeared related to the occurrence of MI: 1) abrupt propranolol withdrawal 24 hours prior to surgery (Prop) (32%, 33/103); 2) left main coronary artery disease (LMCD) (37%, 7/19); and 3) cardiopulmonary bypass longer than 60 minutes (CPB) (23%, 30/128) [7].

Analytical, diagnostic and therapeutic context of LMCD1


  1. Multivariate discriminant analysis of the clinical and angiographic predictors of operative mortality from the Collaborative Study in Coronary Artery Surgery (CASS). Kennedy, J.W., Kaiser, G.C., Fisher, L.D., Maynard, C., Fritz, J.K., Myers, W., Mudd, J.G., Ryan, T.J., Coggin, J. J. Thorac. Cardiovasc. Surg. (1980) [Pubmed]
  2. A qualitative assessment of biotinidase deficiency. Bankson, D.D., Martin, R.P., Forman, D.T. Ann. Clin. Lab. Sci. (1987) [Pubmed]
  3. Coronary surgery for unstable angina pectoris. Incidence and mortality of perioperative myocardial infarction. Langou, R.A., Wiles, J.C., Cohen, L.S. British heart journal. (1978) [Pubmed]
  4. Comparison of surgical and medical group survival in patients with left main coronary artery disease. Long-term CASS experience. Caracciolo, E.A., Davis, K.B., Sopko, G., Kaiser, G.C., Corley, S.D., Schaff, H., Taylor, H.A., Chaitman, B.R. Circulation (1995) [Pubmed]
  5. Identification of a novel LIM domain gene, LMCD1, and chromosomal localization in human and mouse. Bespalova, I.N., Burmeister, M. Genomics (2000) [Pubmed]
  6. cDNA cloning, sequence analysis of the porcine LIM and cysteine-rich domain 1 gene. Wang, J., Deng, C.Y., Xiong, Y.Z., Zuo, B., Xing, L., Li, F.E., Lei, M.G., Zheng, R., Jiang, S.W. Acta Biochim. Biophys. Sin. (Shanghai) (2005) [Pubmed]
  7. Incidence and mortality of perioperative myocardial infarction in patients undergoing coronary artery bypass grafting. Langou, R.A., Wiles, J.C., Peduzzi, P.N., Hammond, G.L., Cohen, L.S. Circulation (1977) [Pubmed]
  8. Off-pump coronary artery grafting in patients with left main coronary artery disease. Virani, S.S., Lombardi, P., Tehrani, H., Masroor, S., Yassin, S., Salerno, T., Bolooki, H., Katariya, K. Journal of cardiac surgery. (2005) [Pubmed]
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