Disease relevance of gefiltin

• Cloning of zebrafish neurofilament cDNAs for plasticin and gefiltin: increased mRNA expression in ganglion cells after optic nerve injury [1].

High impact information on gefiltin

• In addition, the cDNAs for zebrafish plasticin and gefiltin were cloned and characterized [1].
• The successive expression of plasticin and gefiltin suggests that these neuronal intermediate filament proteins are integral components of axonogenesis [1].
• Outside of the visual pathway, gefiltin is predominantly expressed in the central nervous system whereas plasticin is primarily expressed in the peripheral nervous system [2].
• Gefiltin in zebrafish embryos: sequential gene expression of two neurofilament proteins in retinal ganglion cells [2].

Anatomical context of gefiltin

• Thus, during RGC development, expression of plasticin and gefiltin resembles that with optic nerve regeneration [2].
• In the teleost visual pathway, the sequential expression of two IF genes, plasticin and gefiltin, is linked to the age of retinal ganglion cells (RGCs) and to the regeneration of optic axons after nerve injury [2].
• Gefiltin is expressed after plasticin, during the later stages of retinal development when axons grow past the optic chiasm and innervate their targets [2].

Other interactions of gefiltin

• We analyzed the pattern of gefiltin expression during zebrafish development and compared it to our previous determination of plasticin expression (Canger et al. 1998) [2].

References