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Gene Review

kita  -  v-kit Hardy-Zuckerman 4 feline sarcoma...

Danio rerio

Synonyms: Mast/stem cell growth factor receptor kita, SCFR, SO:0000704, Tyrosine-protein kinase Kit, c-kit, ...
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Disease relevance of kita


High impact information on kita

  • We also find that, in contrast to mouse, the zebrafish c-kit gene that we have identified is not essential for hematopoiesis or primordial germ cell development [2].
  • Expression of c-kit, which encodes the receptor for the Steel ligand, is reduced in these embryos, and, similar to zebrafish c-kit mutant embryos, embryonic melanophores are reduced in number and migration [3].
  • We show that in embryos, kitb is expressed in a non-overlapping pattern to that of kita, in the anterior ventral mesoderm, Rohon-beardRohon-Beard neurons, the otic vesicle, and trigeminal ganglia [4].

Biological context of kita


  1. Gene Duplication of the zebrafish kit ligand and partitioning of melanocyte development functions to kit ligand a. Hultman, K.A., Bahary, N., Zon, L.I., Johnson, S.L. PLoS Genet. (2007) [Pubmed]
  2. Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell development. Parichy, D.M., Rawls, J.F., Pratt, S.J., Whitfield, T.T., Johnson, S.L. Development (1999) [Pubmed]
  3. Transcription factor Ap-2alpha is necessary for development of embryonic melanophores, autonomic neurons and pharyngeal skeleton in zebrafish. O'Brien, E.K., d'Alençon, C., Bonde, G., Li, W., Schoenebeck, J., Allende, M.L., Gelb, B.D., Yelon, D., Eisen, J.S., Cornell, R.A. Dev. Biol. (2004) [Pubmed]
  4. kitb, a second zebrafish ortholog of mouse Kit. Mellgren, E.M., Johnson, S.L. Dev. Genes Evol. (2005) [Pubmed]
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