Gene Review:
Kit - kit oncogene
Mus musculus
Synonyms:
Bs, CD117, Dominant white spotting, Fdc, Gsfsco1, ...
- Resistance to friend virus-induced erythroleukemia in W/W(v) mice is caused by a spleen-specific defect which results in a severe reduction in target cells and a lack of Sf-Stk expression. Subramanian, A., Teal, H.E., Correll, P.H., Paulson, R.F. J. Virol. (2005)
- Enhancement of murine blast cell colony formation in culture by recombinant rat stem cell factor, ligand for c-kit. Tsuji, K., Zsebo, K.M., Ogawa, M. Blood (1991)
- c-kit marks late retinal progenitor cells and regulates their differentiation in developing mouse retina. Koso, H., Satoh, S., Watanabe, S. Dev. Biol. (2007)
- W/Wv marrow stromal cells engraft and enhance early erythropoietic progenitors in unconditioned Sl/Sld murine recipients. Bubnic, S.J., Wang, X.H., Clark, B.R., Keating, A. Bone Marrow Transplant. (2002)
- Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1. Piao, X., Paulson, R., van der Geer, P., Pawson, T., Bernstein, A. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit. Sun, J., Pedersen, M., Rönnstrand, L. J. Biol. Chem. (2008)
- Interaction of stem cell factor and its receptor c-kit mediates lodgment and acute expansion of hematopoietic cells in the murine spleen. Broudy, V.C., Lin, N.L., Priestley, G.V., Nocka, K., Wolf, N.S. Blood (1996)
- The interstitial cells of Cajal and a gastroenteric pacemaker system. Takayama, I., Horiguchi, K., Daigo, Y., Mine, T., Fujino, M.A., Ohno, S. Arch. Histol. Cytol. (2002)
- Effects of G-protein mutations on skin color. Van Raamsdonk, C.D., Fitch, K.R., Fuchs, H., de Angelis, M.H., Barsh, G.S. Nat. Genet. (2004)
- Oligo-astheno-teratozoospermia in mice lacking Cnot7, a regulator of retinoid X receptor beta. Nakamura, T., Yao, R., Ogawa, T., Suzuki, T., Ito, C., Tsunekawa, N., Inoue, K., Ajima, R., Miyasaka, T., Yoshida, Y., Ogura, A., Toshimori, K., Noce, T., Yamamoto, T., Noda, T. Nat. Genet. (2004)
- Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. McGill, G.G., Horstmann, M., Widlund, H.R., Du, J., Motyckova, G., Nishimura, E.K., Lin, Y.L., Ramaswamy, S., Avery, W., Ding, H.F., Jordan, S.A., Jackson, I.J., Korsmeyer, S.J., Golub, T.R., Fisher, D.E. Cell (2002)
- Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3'-kinase is essential for male fertility. Blume-Jensen, P., Jiang, G., Hyman, R., Lee, K.F., O'Gorman, S., Hunter, T. Nat. Genet. (2000)
- Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1. Paulson, R.F., Vesely, S., Siminovitch, K.A., Bernstein, A. Nat. Genet. (1996)
- Structure and regulation of Kit protein-tyrosine kinase--the stem cell factor receptor. Roskoski, R. Biochem. Biophys. Res. Commun. (2005)
- Bone marrow norepinephrine mediates development of functionally different macrophages after thermal injury and sepsis. Cohen, M.J., Shankar, R., Stevenson, J., Fernandez, R., Gamelli, R.L., Jones, S.B. Ann. Surg. (2004)
- Mastocytosis in mice expressing human Kit receptor with the activating Asp816Val mutation. Zappulla, J.P., Dubreuil, P., Desbois, S., Létard, S., Hamouda, N.B., Daëron, M., Delsol, G., Arock, M., Liblau, R.S. J. Exp. Med. (2005)
- The multi-targeted kinase inhibitor SU5416 inhibits small cell lung cancer growth and angiogenesis, in part by blocking Kit-mediated VEGF expression. Litz, J., Sakuntala Warshamana-Greene, G., Sulanke, G., Lipson, K.E., Krystal, G.W. Lung Cancer (2004)
- Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase. Reith, A.D., Ellis, C., Lyman, S.D., Anderson, D.M., Williams, D.E., Bernstein, A., Pawson, T. EMBO J. (1991)
- Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells. Serve, H., Yee, N.S., Stella, G., Sepp-Lorenzino, L., Tan, J.C., Besmer, P. EMBO J. (1995)
- Steel mutant mice are deficient in hippocampal learning but not long-term potentiation. Motro, B., Wojtowicz, J.M., Bernstein, A., van der Kooy, D. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Physical mapping of the Tec and Gabrb1 loci reveals that the Wsh mutation on mouse chromosome 5 is associated with an inversion. Nagle, D.L., Kozak, C.A., Mano, H., Chapman, V.M., Bućan, M. Hum. Mol. Genet. (1995)
- Critical roles of c-Kit tyrosine residues 567 and 719 in stem cell factor-induced chemotaxis: contribution of src family kinase and PI3-kinase on calcium mobilization and cell migration. Ueda, S., Mizuki, M., Ikeda, H., Tsujimura, T., Matsumura, I., Nakano, K., Daino, H., Honda Zi, Z., Sonoyama, J., Shibayama, H., Sugahara, H., Machii, T., Kanakura, Y. Blood (2002)
- Spatial and temporal patterns of c-kit-expressing cells in WlacZ/+ and WlacZ/WlacZ mouse embryos. Bernex, F., De Sepulveda, P., Kress, C., Elbaz, C., Delouis, C., Panthier, J.J. Development (1996)
- Expression and function of c-Kit in fetal hemopoietic progenitor cells: transition from the early c-Kit-independent to the late c-Kit-dependent wave of hemopoiesis in the murine embryo. Ogawa, M., Nishikawa, S., Yoshinaga, K., Hayashi, S., Kunisada, T., Nakao, J., Kina, T., Sudo, T., Kodama, H., Nishikawa, S. Development (1993)
- Kit signaling inhibits the sphingomyelin-ceramide pathway through PLC gamma 1: implication in stem cell factor radioprotective effect. Maddens, S., Charruyer, A., Plo, I., Dubreuil, P., Berger, S., Salles, B., Laurent, G., Jaffrézou, J.P. Blood (2002)
- Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, phosphatidylinositol 3'-kinase, and protein kinase C. Yee, N.S., Hsiau, C.W., Serve, H., Vosseller, K., Besmer, P. J. Biol. Chem. (1994)
- Tr-kit-induced resumption of the cell cycle in mouse eggs requires activation of a Src-like kinase. Sette, C., Paronetto, M.P., Barchi, M., Bevilacqua, A., Geremia, R., Rossi, P. EMBO J. (2002)
- Steel factor and c-kit regulate cell-matrix adhesion. Kinashi, T., Springer, T.A. Blood (1994)
- Dynamic changes in ovarian c-kit and Steel expression during the estrous reproductive cycle. Motro, B., Bernstein, A. Dev. Dyn. (1993)
- c-Kit in early onset of diabetes: a morphological and functional analysis of pancreatic beta-cells in c-KitW-v mutant mice. Krishnamurthy, M., Ayazi, F., Li, J., Lyttle, A.W., Woods, M., Wu, Y., Yee, S.P., Wang, R. Endocrinology (2007)
- Steel factor and c-kit receptor: from mutants to a growth factor system. Morrison-Graham, K., Takahashi, Y. Bioessays (1993)
- Residual erythroid progenitors in W/W mice respond to erythropoietin in the absence of steel factor signals. Pharr, P.N., Hofbauer, A., Worthington, R.E., Longmore, G.D. Int. J. Hematol. (2000)
- The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor. Rottapel, R., Reedijk, M., Williams, D.E., Lyman, S.D., Anderson, D.M., Pawson, T., Bernstein, A. Mol. Cell. Biol. (1991)
- The rat c-kit ligand, stem cell factor, induces c-kit receptor-dependent mouse mast cell activation in vivo. Evidence that signaling through the c-kit receptor can induce expression of cellular function. Wershil, B.K., Tsai, M., Geissler, E.N., Zsebo, K.M., Galli, S.J. J. Exp. Med. (1992)
- Low c-kit expression of cultured mast cells of mi/mi genotype may be involved in their defective responses to fibroblasts that express the ligand for c-kit. Ebi, Y., Kanakura, Y., Jippo-Kanemoto, T., Tsujimura, T., Furitsu, T., Ikeda, H., Adachi, S., Kasugai, T., Nomura, S., Kanayama, Y. Blood (1992)
- Deficiency of Trp53 rescues the male fertility defects of Kit(W-v) mice but has no effect on the survival of melanocytes and mast cells. Jordan, S.A., Speed, R.M., Bernex, F., Jackson, I.J. Dev. Biol. (1999)
- Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor. Zsebo, K.M., Williams, D.A., Geissler, E.N., Broudy, V.C., Martin, F.H., Atkins, H.L., Hsu, R.Y., Birkett, N.C., Okino, K.H., Murdock, D.C. Cell (1990)
- Structural analysis of chromosomal rearrangements associated with the developmental mutations Ph, W19H, and Rw on mouse chromosome 5. Nagle, D.L., Martin-DeLeon, P., Hough, R.B., Bućan, M. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Rump white inversion in the mouse disrupts dipeptidyl aminopeptidase-like protein 6 and causes dysregulation of Kit expression. Hough, R.B., Lengeling, A., Bedian, V., Lo, C., Bućan, M. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Thrombopoietin, but not erythropoietin, directly stimulates multilineage growth of primitive murine bone marrow progenitor cells in synergy with early acting cytokines: distinct interactions with the ligands for c-kit and FLT3. Ramsfjell, V., Borge, O.J., Veiby, O.P., Cardier, J., Murphy, M.J., Lyman, S.D., Lok, S., Jacobsen, S.E. Blood (1996)
- A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit. Matthews, W., Jordan, C.T., Gavin, M., Jenkins, N.A., Copeland, N.G., Lemischka, I.R. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Repression of c-kit and its downstream substrates by GATA-1 inhibits cell proliferation during erythroid maturation. Munugalavadla, V., Dore, L.C., Tan, B.L., Hong, L., Vishnu, M., Weiss, M.J., Kapur, R. Mol. Cell. Biol. (2005)
- Melanocyte development in vivo and in neural crest cell cultures: crucial dependence on the Mitf basic-helix-loop-helix-zipper transcription factor. Opdecamp, K., Nakayama, A., Nguyen, M.T., Hodgkinson, C.A., Pavan, W.J., Arnheiter, H. Development (1997)
- Stem cell factor activates STAT-5 DNA binding in IL-3-derived bone marrow mast cells. Ryan, J.J., Huang, H., McReynolds, L.J., Shelburne, C., Hu-Li, J., Huff, T.F., Paul, W.E. Exp. Hematol. (1997)