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Gene Review

Kit  -  v-kit Hardy-Zuckerman 4 feline sarcoma...

Rattus norvegicus

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Disease relevance of Kit

  • These data implicate Kit as one of the components leading to the Schwann cell hyperplasia observed in NF1 [1].
  • Mutations in the genes encoding the Kit tyrosine kinase receptor or kit ligand (KL) cause numerous phenotypic defects, including sterility [2].

High impact information on Kit

  • The Src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases [3].
  • Flt3/Flk2 belongs to a family of receptors, including Kit and colony-stimulating factor-1R, which support growth and differentiation within the hematopoietic system [4].
  • In distinction to Kit and colony-stimulating factor-1R, mutant receptors unable to couple to PI3K and expressed in rodent fibroblasts or in the interleukin 3-dependent cell line Ba/F3 provide a mitogenic signal comparable to wild-type receptors [4].
  • The membrane-anchored forms of transforming growth factor-alpha (TGF-alpha) and stem cell growth factors (Kit ligands) KL-1 and KL-2 are converted to soluble growth factor forms by a regulated proteolytic cleavage process [5].
  • KL mRNA and protein were detected in the OSE cell layer of rat ovaries, and primary cultures of rat OSE as well as the immortalized rat OSE cell line, ROSE 199, expressed KL, but not Kit receptors [6].

Biological context of Kit


Anatomical context of Kit

  • The expression of mostly soluble KL in the surface epithelium suggests that this cytokine may be acting in a paracrine fashion, perhaps interacting with nearby Kit receptor-bearing theca cells [6].
  • High levels of Kit expression in the neurofibrosarcoma-derived Schwann cells correlate with a decrease in neurofibromin expression [1].
  • In the postnatal ovary, Kit is expressed on the oocyte surface and KL is produced by the surrounding granulosa cells, but its function in these cells is still unknown [2].
  • Coupling of the Kit receptor protein on gonocytes to stem cell factor from Sertoli cells is vital for successful migration by gonocytes, as antagonism of the former suppresses and addition of the latter stimulates gonocyte migration [11].
  • Spontaneous phasic contractions were irregular in the distended intestinal regions of ETB(-/-) rats, and this was associated with an increased number of macrophages and damage to interstitial cells of Cajal (ICC) as revealed by using Kit-like immunoreactivity and electron microscopy [12].

Associations of Kit with chemical compounds

  • Thus, KL-activated Kit inhibits meiotic progression, and the in vivo luteinizing hormone-stimulated resumption of meiosis may negate Kit activity by a localized decrease in KL expression and by altering the form of KL produced within the follicle [2].
  • The RIA of the generated angiotensin I is carried out with the commercially available NEN Kit [13].
  • For immunohistochemical analysis, the labeled streptavidin biotin method was performed using a Vectastain Universal Quick Kit with microwave accentuation [14].
  • Two different HEDP content kits (Kit A, HEDP: 1 mg, SnCl2. 2H2O: 0.5 mg; and Kit B, HEDP: 10 mg, SnCl2. 2H2O: 0.5 mg) were evaluated for their stability against dilution 99mTc-HEDP solutions prepared from these two kits were diluted from 10 to 6000fold with 0.9% NaCl solution just before evaluation both in vivo and in vitro [15].

Analytical, diagnostic and therapeutic context of Kit

  • This, together with the easy Kit preparation, makes [123I]-2-iodo-L-phenylalanine a promising tumor specific tracer for SPECT [16].
  • For detection of DNA breaks (apoptosis) in the cells of the seminiferous epithelium, the testicular sections were treated by the TUNEL method (Apop-Tag Plus Peroxidase Kit) [17].
  • Mucosal scrapings were extracted in 2 ml Krebs-Hemselest buffer for determination of interleukins-2, 6 and 10 using the Biosource International Immunoassay Kit [18].
  • Serum concentration of the cross-linked carboxyterminal telopeptide of type I collagen was analyzed by the Rat Telopeptide [125I]ICTP Radioimmunoassay Kit obtained from Orion Diagnostica (Finland) [19].
  • Western immunoblotting confirmed the low recovery of tetrameric TTR by the 2-D Clean-Up Kit and showed that the tetrameric form of TTR predominated in ovine but not in rat CSF [20].


  1. Expression of Kit in neurofibromin-deficient human Schwann cells: role in Schwann cell hyperplasia associated with type 1 neurofibromatosis. Badache, A., Muja, N., De Vries, G.H. Oncogene (1998) [Pubmed]
  2. Hormonally regulated expression and alternative splicing of kit ligand may regulate kit-induced inhibition of meiosis in rat oocytes. Ismail, R.S., Dubé, M., Vanderhyden, B.C. Dev. Biol. (1997) [Pubmed]
  3. The Src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases. Tatton, L., Morley, G.M., Chopra, R., Khwaja, A. J. Biol. Chem. (2003) [Pubmed]
  4. Phosphatidylinositol-3' kinase is not required for mitogenesis or internalization of the Flt3/Flk2 receptor tyrosine kinase. Beslu, N., LaRose, J., Casteran, N., Birnbaum, D., Lecocq, E., Dubreuil, P., Rottapel, R. J. Biol. Chem. (1996) [Pubmed]
  5. Cleavage of membrane-anchored growth factors involves distinct protease activities regulated through common mechanisms. Pandiella, A., Bosenberg, M.W., Huang, E.J., Besmer, P., Massagué, J. J. Biol. Chem. (1992) [Pubmed]
  6. Transforming growth factor-beta regulates Kit ligand expression in rat ovarian surface epithelial cells. Ismail, R.S., Cada, M., Vanderhyden, B.C. Oncogene (1999) [Pubmed]
  7. Nonradiochemical DNase I footprinting by capillary electrophoresis. Wilson, D.O., Johnson, P., McCord, B.R. Electrophoresis (2001) [Pubmed]
  8. Effect of heat shock and endotoxin stress on enterocyte viability apoptosis and function varies based on whether the cells are exposed to heat shock or endotoxin first. Xu, D.Z., Lu, Q., Swank, G.M., Deitch, E.A. Archives of surgery (Chicago, Ill. : 1960) (1996) [Pubmed]
  9. Relationship between lymphocyte apoptosis and endotoxin translocation after thermal injury in rats. Xia, P.Y., Zheng, J., Zhou, H., Pan, W.D., Qin, X.J., Xiao, G.X. World J. Gastroenterol. (2002) [Pubmed]
  10. Piracetam and vinpocetine exert cytoprotective activity and prevent apoptosis of astrocytes in vitro in hypoxia and reoxygenation. Gabryel, B., Adamek, M., Pudełko, A., Małecki, A., Trzeciak, H.I. Neurotoxicology (2002) [Pubmed]
  11. Gonocyte-Sertoli cell interactions during development of the neonatal rodent testis. Orth, J.M., Jester, W.F., Li, L.H., Laslett, A.L. Curr. Top. Dev. Biol. (2000) [Pubmed]
  12. Muscularis inflammation and the loss of interstitial cells of Cajal in the endothelin ETB receptor null rat. Suzuki, T., Won, K.J., Horiguchi, K., Kinoshita, K., Hori, M., Torihashi, S., Momotani, E., Itoh, K., Hirayama, K., Ward, S.M., Sanders, K.M., Ozaki, H. Am. J. Physiol. Gastrointest. Liver Physiol. (2004) [Pubmed]
  13. A simple radioimmunological method for the determination or renal renin activity in the rat. Serban, I., Gavendo, S., Modan, M. J. Lab. Clin. Med. (1977) [Pubmed]
  14. Variable E-cadherin expression in a MNU-induced colon tumor model in rats which exposed with 50 Hz frequency sinusoidal magnetic field. Tuncel, H., Shimamoto, F., Cagatay, P., Kalkan, M.T. Tohoku J. Exp. Med. (2002) [Pubmed]
  15. Evaluation of two different HEDP content kits: stability study against dilution both in vivo and in vitro. Inoue, O., Ikeda, I., Kurata, K. Nuklearmedizin. (1982) [Pubmed]
  16. Synthesis, radiosynthesis, and in vitro characterization of [125I]-2- iodo-L-phenylalanine in a R1M rhabdomyosarcoma cell model as a new potential tumor tracer for SPECT. Mertens, J., Kersemans, V., Bauwens, M., Joos, C., Lahoutte, T., Bossuyt, A., Slegers, G. Nucl. Med. Biol. (2004) [Pubmed]
  17. In situ demonstration of both TUNEL-labeled germ cell and Sertoli cell in the cimetidine-treated rats. Sasso-Cerri, E., Miraglia, S.M. Histol. Histopathol. (2002) [Pubmed]
  18. Divergent effects of nicotine administration on cytokine levels in rat small bowel mucosa, colonic mucosa, and blood. Eliakim, R., Karmeli, F. Isr. Med. Assoc. J. (2003) [Pubmed]
  19. Concentration of the cross-linked carboxyterminal telopeptide of type I collagen in serum of young growing rats fed a low calcium and vitamin D-deficient diet. Bielaczyc, A.R., Gołebiewska, M., Citko, A., Rogowski, F. European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies. (1997) [Pubmed]
  20. Optimising ovine cerebrospinal fluid preparation for two-dimensional gel electrophoresis. Chen, R.L., Sage, E.A., Dunn, M.J., Wait, R., Preston, J.E. Proteomics (2006) [Pubmed]
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