High impact information on pou50

• Correct zp-50 expression in the ventral fore- and midbrain requires genes known to be involved in dorsoventral patterning of the zebrafish CNS [1].
• We report the characterization of the zebrafish zp-50 class III POU domain gene [1].
• Injection of synthetic shh mRNA into fertilized eggs causes ectopic zp-50 expression at more dorsal positions of the embryonic brain [1].
• Transcripts of the sonic hedgehog (shh) gene encoding an intercellular signaling molecule are detected in the forming diencephalon shortly prior to the appearance of zp-50 mRNA [1].
• During somitogenesis, zp-50 is expressed in a very dynamic and complex fashion in all major subdivisions of the central nervous system [1].

Anatomical context of pou50

• After one day of development, zp-50 transcripts are present in the fore- and midbrain in several distinct cell clusters [1].
• In the hindbrain, zp-50 expression is found in two types of domains [1].

References