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MeSH Review

Supine Position

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Disease relevance of Supine Position


Psychiatry related information on Supine Position

  • MEASUREMENTS AND RESULTS: We observed that CO2 could increase upper-airway muscle activity during NREM sleep and wakefulness in the supine position with and without intrapharyngeal negative pressure [6].

High impact information on Supine Position

  • In addition, the Chinese subjects had much greater sensitivity to the hypotensive effects of propranolol, as shown by the concentrations that reduced blood pressure by 10 percent in the supine position (73 +/- 5 vs. 748 +/- 7 nmol per liter; P less than 0.01) and in the upright position (89 +/- 5 vs. 401 +/- 6 nmol per liter; P less than 0.01) [7].
  • Studies of homeotic mutants have shown that a structure in one disk is always transformed into a specific structure from the other disk(5,6); for example clones of bithorax in an anterior dorsal position in the haltere show anterior dorsal wing structures(5) [8].
  • All the subjects with MSA had low plasma norepinephrine concentrations (in the supine position) (0.42 +/- 0.09 nM, normal 3.47 +/- 0.58 nM), which did not increase on tilt [9].
  • METHODS: Renal function and plasma atrial natriuretic factor (ANF), aldosterone, and norepinephrine levels were determined after 2 hours of standing and 30, 60, and 120 minutes after taking up the supine position in 10 patients and 10 healthy subjects [10].
  • Alinidine 80 mg reduced arterial pressure in the standing and supine positions [11].

Chemical compound and disease context of Supine Position


Biological context of Supine Position


Anatomical context of Supine Position


Associations of Supine Position with chemical compounds

  • Responses to isoproterenol were not significantly different between group II and controls in supine position [27].
  • In study 1, there were no effects of angiotensin II on heart rate, plasma norepinephrine, norepinephrine clearance or norepinephrine spillover compared with the vehicle control when the patient was in the supine position [20].
  • After 20 min of 70 degrees upright tilting, the table was returned to supine position at a speed of 3.2 degrees/s. Subsequently, BRS was assessed using an intravenous bolus injection of phenylephrine (2 to 3 microg/kg) [28].
  • After 1 month under normal Na+ intake (120 mmol Na+ per day), patients were randomly assigned to receive either ANP (0.04 (n = 15) or vehicle (50 ml saline) (n = 7) over a 60-min period, while in the supine position [29].
  • Acid clearance tests were performed in 10 healthy subjects in the upright and supine positions, before and after oesophageal peristaltic disruption with sildenafil 50 mg [30].

Gene context of Supine Position

  • In patients, we found negative correlations between endothelin-3, but not endothelin-1, and mean arterial pressure, both in upright (r = -0.59; p < 0.01) and supine (r = -0.56; p = 0.01) positions, atrial natriuretic factor (r = 0.50; p < 0.05) and plasma renin activity (r = 0.67; p = 0.001) in the supine position alone [4].
  • MEASUREMENTS: Tidal FL was assessed in 117 ambulatory COPD patients in sitting and supine positions using the negative expiratory pressure method [31].
  • Nine healthy men, mean age 31 years (range 24-41), received single blind with at least one week apart, after resting in the supine position for 30 min, AVP 0.26 microgram/kg body weight i.v. (Pitressin, Parke-Davis) or saline in randomized order [32].
  • In supine position at zero PEEP, 10 patients exhibited EFL with a significantly higher PEEPi and DH and a significantly lower PEEPi inequality index than found in the five non-EFL (NEFL) subjects [33].
  • We compared the results obtained by Prolonged Position with two other physical therapies by dividing our horizontal canal BPPV patients into three therapeutic groups: 1) 35 patients treated with Prolonged Position; 2) 24 patients treated with head shaking in a supine position; 3) 15 patients for whom therapy was omitted [34].

Analytical, diagnostic and therapeutic context of Supine Position


  1. Clinical and metabolic correction of pompe disease by enzyme therapy in acid maltase-deficient quail. Kikuchi, T., Yang, H.W., Pennybacker, M., Ichihara, N., Mizutani, M., Van Hove, J.L., Chen, Y.T. J. Clin. Invest. (1998) [Pubmed]
  2. Abnormal regulation of antidiuretic hormone in idiopathic edema. Thibonnier, M., Marchetti, J., Corvol, P., Menard, J., Milliez, P. Am. J. Med. (1979) [Pubmed]
  3. Acute and chronic effects of molsidomine on pulmonary artery pressure and work capacity in patients with coronary heart disease. Jansen, W., Eggeling, T., Meyer, L., Tauchert, M., Hilger, H.H. Eur. Heart J. (1987) [Pubmed]
  4. Plasma endothelin-1 and -3 in cirrhosis: relationship with systemic hemodynamics, renal function and neurohumoral systems. Bernardi, M., Gulberg, V., Colantoni, A., Trevisani, F., Gasbarrini, A., Gerbes, A.L. J. Hepatol. (1996) [Pubmed]
  5. Effect of the somatostatin analogue, octreotide, on exercise-induced hypotension in human subjects with chronic sympathetic failure. Smith, G.D., Alam, M., Watson, L.P., Mathias, C.J. Clin. Sci. (1995) [Pubmed]
  6. Genioglossal muscle response to CO2 stimulation during NREM sleep. Lo, Y.L., Jordan, A.S., Malhotra, A., Wellman, A., Heinzer, R.C., Schory, K., Dover, L., Fogel, R.B., White, D.P. Sleep. (2006) [Pubmed]
  7. Altered sensitivity to and clearance of propranolol in men of Chinese descent as compared with American whites. Zhou, H.H., Koshakji, R.P., Silberstein, D.J., Wilkinson, G.R., Wood, A.J. N. Engl. J. Med. (1989) [Pubmed]
  8. A major difference between transdetermination and homeosis. Karlsson, J. Nature (1979) [Pubmed]
  9. Increased numbers of alpha receptors in sympathetic denervation supersensitivity in man. Davies, B., Sudera, D., Sagnella, G., Marchesi-Saviotti, E., Mathias, C., Bannister, R., Sever, P. J. Clin. Invest. (1982) [Pubmed]
  10. Renal sodium retention during upright posture in preascitic cirrhosis. Bernardi, M., Di Marco, C., Trevisani, F., Fornalè, L., Andreone, P., Cursaro, C., Baraldini, M., Ligabue, A., Tamè, M.R., Gasbarrini, G. Gastroenterology (1993) [Pubmed]
  11. Alinidine reduces heart-rate without blockade of beta-adrenoceptors. Harron, D.W., Riddell, J.G., Shanks, R.G. Lancet (1981) [Pubmed]
  12. A controlled trial of labetalol (Trandate), propranolol and placebo in the management of mild to moderate hypertension. Pugsley, D.J., Nassim, M., Armstrong, B.K., Beilin, L. British journal of clinical pharmacology. (1979) [Pubmed]
  13. Levobupivacaine vs bupivacaine as infiltration anaesthesia in inguinal herniorrhaphy. Bay-Nielsen, M., Klarskov, B., Bech, K., Andersen, J., Kehlet, H. British journal of anaesthesia. (1999) [Pubmed]
  14. Prospective study of angiotensin II response to positional change in pregnancy-induced hypertension. Hayashi, R.H., Becker, R.A., Evans, G.T., Morris, K., Franks, R.C. Am. J. Obstet. Gynecol. (1977) [Pubmed]
  15. Shy-Drager syndrome and severe unexplained intraoperative hypotension responsive to vasopressin. Vallejo, R., DeSouza, G., Lee, J. Anesth. Analg. (2002) [Pubmed]
  16. Microsurgery of Arnold-Chiari malformation in adults with and without hydromyelia. Rhoton, A.L. J. Neurosurg. (1976) [Pubmed]
  17. How gastric emptying of carbohydrate affects glucose tolerance and symptoms after truncal vagotomy with pyloroplasty. Gulsrud, P.O., Taylor, I.L., Watts, H.D., Cohen, M.B., Elashoff, J., Meyer, J.H. Gastroenterology (1980) [Pubmed]
  18. Treatment of chronic orthostatic hypotension with ergotamine. Chobanian, A.V., Tifft, C.P., Faxon, D.P., Creager, M.A., Sackel, H. Circulation (1983) [Pubmed]
  19. Overall safety of terazosin as an antihypertensive agent. Sperzel, W.D., Glassman, H.N., Jordan, D.C., Luther, R.R. Am. J. Med. (1986) [Pubmed]
  20. Angiotensin II and sympathetic activity in patients with congestive heart failure. Goldsmith, S.R., Hasking, G.J., Miller, E. J. Am. Coll. Cardiol. (1993) [Pubmed]
  21. Renal dysfunction as a possible cause of essential hypertension in predisposed subjects. Bianchi, G., Cusi, D., Barlassina, C., Lupi, G.P., Ferrari, P., Picotti, G.B., Gatti, M., Polli, E. Kidney Int. (1983) [Pubmed]
  22. Complex expression of the zp-50 pou gene in the embryonic zebrafish brain is altered by overexpression of sonic hedgehog. Hauptmann, G., Gerster, T. Development (1996) [Pubmed]
  23. Human galanin reduces plasma norepinephrine levels in man. degli Uberti, E.C., Ambrosio, M.R., Bondanelli, M., Trasforini, G., Margutti, A., Valentini, A., Rossi, R., Franceschetti, P. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  24. Effects of physiological and pharmacological variation of sympathetic nervous system activity on plasma non-esterified fatty acid concentrations in man. Barbe, P., Galitzky, J., Riviere, D., Senard, J.M., Lafontan, M., Garrigues, M., Berlan, M. British journal of clinical pharmacology. (1993) [Pubmed]
  25. Anatomical configuration of the spinal column in the supine position. III. Comparison of adolescent and adult volunteers. Hirabayashi, Y., Shimizu, R., Saitoh, K., Fukuda, H., Igarashi, T., Furuse, M. British journal of anaesthesia. (1996) [Pubmed]
  26. Arterial hypoxemia following the administration of sublingual nitroglycerin. Kopman, E.A., Weygandt, G.R., Bauer, S., Ferguson, T.B. Am. Heart J. (1978) [Pubmed]
  27. Distinct hemodynamic profiles in patients with vasovagal syncope: a heterogeneous population. Shen, W.K., Low, P.A., Rea, R.F., Lohse, C.M., Hodge, D.O., Hammill, S.C. J. Am. Coll. Cardiol. (2000) [Pubmed]
  28. Noninvasive assessment of the cardiac baroreflex: response to downward tilting and comparison with the phenylephrine method. Takahashi, N., Nakagawa, M., Saikawa, T., Ooie, T., Akimitsu, T., Kaneda, K., Hara, M., Iwao, T., Yonemochi, H., Ito, M., Sakata, T. J. Am. Coll. Cardiol. (1999) [Pubmed]
  29. Salt-sensitivity is associated with a hyperinsulinaemic and hyperglycaemic response to atrial natriuretic peptide infusion in human essential hypertension. Ferri, C., Bellini, C., Desideri, G., Di Francesco, L., De Mattia, G., Santucci, A., Balsano, F. Diabetologia (1994) [Pubmed]
  30. Relevance of ineffective oesophageal motility during oesophageal acid clearance. Simrén, M., Silny, J., Holloway, R., Tack, J., Janssens, J., Sifrim, D. Gut (2003) [Pubmed]
  31. Orthopnea and tidal expiratory flow limitation in patients with stable COPD. Eltayara, L., Ghezzo, H., Milic-Emili, J. Chest (2001) [Pubmed]
  32. Release of prolactin as well as adrenocorticotropin after administration of arginine-vasopressin to healthy men. Erfurth, E.M., Hedner, P., Lundin, S., Ekman, R. Horm. Metab. Res. (1996) [Pubmed]
  33. Expiratory flow limitation in morbidly obese postoperative mechanically ventilated patients. Koutsoukou, A., Koulouris, N., Bekos, B., Sotiropoulou, C., Kosmas, E., Papadima, K., Roussos, C. Acta anaesthesiologica Scandinavica. (2004) [Pubmed]
  34. Treatment of horizontal semicircular canal benign paroxysmal positional vertigo. Vannucchi, P., Giannoni, B., Pagnini, P. Journal of vestibular research : equilibrium & orientation. (1997) [Pubmed]
  35. 99mTc-HMPAO brain SPECT imaging in a case of repeated syncopal episodes associated with smoking. Fukuda, H., Kitani, M., Omodani, H. Stroke (1997) [Pubmed]
  36. The response of plasma catecholamines to intravenous labetalol: a comparison with sodium nitroprusside. Lin, M.S., McNay, J.L., Shepherd, A.M., Keeton, T.K. Clin. Pharmacol. Ther. (1983) [Pubmed]
  37. Contributions of upper airway mechanics and control mechanisms to severity of obstructive apnea. Younes, M. Am. J. Respir. Crit. Care Med. (2003) [Pubmed]
  38. Maladaptation of vascular response in frontal area of patients with orthostatic hypotension. Hayashida, K., Nishiooeda, Y., Hirose, Y., Ishida, Y., Nishimura, T. J. Nucl. Med. (1996) [Pubmed]
  39. Effect of exercise position during stress testing on cardiac and pulmonary thallium kinetics and accuracy in evaluating coronary artery disease. Lear, J.L. J. Nucl. Med. (1986) [Pubmed]
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