The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

eya1  -  EYA transcriptional coactivator and...

Danio rerio

Synonyms: SO:0000704, wu:fc13c10, zgc:100770
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on eya1

  • Furthermore, development in mc2r knockdown morphants does not differ from aal/eya1 and lia/fgf3 mutants [1].
  • In contrast to other organs, adenohypophyseal cells of eya1 mutants do not become apoptotic, and the adenohypophysis remains at rather normal size [2].
  • Furthermore, eya1 is required for maintenance of pit1 expression, leading to subsequent loss of cognate hormone gene expression in thyrotropes and somatotropes of mutant embryos, whereas prolactin expression in lactotropes persists [2].
  • The dog locus encodes the eyes absent-1 (eya1) gene and single point mutations were found in three independent dog alleles, each prematurely truncating the expressed protein within the Eya domain [3].
  • The zebrafish dog-eared mutation disrupts eya1, a gene required for cell survival and differentiation in the inner ear and lateral line [3].

Biological context of eya1


Anatomical context of eya1

  • Unlike in mouse, six1 does not appear to be dependent on eya1, although it seems to be important for the regulation of eya1 and pax2b expression in the ventral otic epithelium [5].


  1. Pituitary-interrenal interaction in zebrafish interrenal organ development. To, T.T., Hahner, S., Nica, G., Rohr, K.B., Hammerschmidt, M., Winkler, C., Allolio, B. Mol. Endocrinol. (2007) [Pubmed]
  2. Eya1 is required for lineage-specific differentiation, but not for cell survival in the zebrafish adenohypophysis. Nica, G., Herzog, W., Sonntag, C., Nowak, M., Schwarz, H., Zapata, A.G., Hammerschmidt, M. Dev. Biol. (2006) [Pubmed]
  3. The zebrafish dog-eared mutation disrupts eya1, a gene required for cell survival and differentiation in the inner ear and lateral line. Kozlowski, D.J., Whitfield, T.T., Hukriede, N.A., Lam, W.K., Weinberg, E.S. Dev. Biol. (2005) [Pubmed]
  4. The zebrafish eya1 gene and its expression pattern during embryogenesis. Sahly, I., Andermann, P., Petit, C. Dev. Genes Evol. (1999) [Pubmed]
  5. The Transcription Factor six1 Inhibits Neuronal and Promotes Hair Cell Fate in the Developing Zebrafish (Danio rerio) Inner Ear. Bricaud, O., Collazo, A. J. Neurosci. (2006) [Pubmed]
WikiGenes - Universities