Gene Review:
Pdx1 - pancreatic and duodenal homeobox 1
Mus musculus
Synonyms:
IDX-1, IPF-1, Insulin promoter factor 1, Ipf1, Islet/duodenum homeobox 1, ...
- Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus. Kim, S.K., Selleri, L., Lee, J.S., Zhang, A.Y., Gu, X., Jacobs, Y., Cleary, M.L. Nat. Genet. (2002)
- NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Kojima, H., Fujimiya, M., Matsumura, K., Younan, P., Imaeda, H., Maeda, M., Chan, L. Nat. Med. (2003)
- Pdx1 restores beta cell function in Irs2 knockout mice. Kushner, J.A., Ye, J., Schubert, M., Burks, D.J., Dow, M.A., Flint, C.L., Dutta, S., Wright, C.V., Montminy, M.R., White, M.F. J. Clin. Invest. (2002)
- Adenovirus Transduction is Required for the Correction of Diabetes Using Pdx-1 or Neurogenin-3 in the Liver. Wang, A.Y., Ehrhardt, A., Xu, H., Kay, M.A. Mol. Ther. (2007)
- Unusual case of neonatal diabetes mellitus due to congenital pancreas agenesis. Ashraf, A., Abdullatif, H., Hardin, W., Moates, J.M. Pediatric diabetes. (2005)
- Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nakae, J., Biggs, W.H., Kitamura, T., Cavenee, W.K., Wright, C.V., Arden, K.C., Accili, D. Nat. Genet. (2002)
- Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas. St-Onge, L., Sosa-Pineda, B., Chowdhury, K., Mansouri, A., Gruss, P. Nature (1997)
- Insulin-promoter-factor 1 is required for pancreas development in mice. Jonsson, J., Carlsson, L., Edlund, T., Edlund, H. Nature (1994)
- Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Fujitani, Y., Fujitani, S., Boyer, D.F., Gannon, M., Kawaguchi, Y., Ray, M., Shiota, M., Stein, R.W., Magnuson, M.A., Wright, C.V. Genes Dev. (2006)
- Development of diabetes mellitus in aging transgenic mice following suppression of pancreatic homeoprotein IDX-1. Thomas, M.K., Devon, O.N., Lee, J.H., Peter, A., Schlosser, D.A., Tenser, M.S., Habener, J.F. J. Clin. Invest. (2001)
- beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Ahlgren, U., Jonsson, J., Jonsson, L., Simu, K., Edlund, H. Genes Dev. (1998)
- Mapping of the insulin promoter factor 1 gene (Ipf1) to distal mouse chromosome 5. Fiedorek, F.T., Kay, E.S. Genomics (1995)
- The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. Kitamura, T., Nakae, J., Kitamura, Y., Kido, Y., Biggs, W.H., Wright, C.V., White, M.F., Arden, K.C., Accili, D. J. Clin. Invest. (2002)
- Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice. Martín, M., Gallego-Llamas, J., Ribes, V., Kedinger, M., Niederreither, K., Chambon, P., Dollé, P., Gradwohl, G. Dev. Biol. (2005)
- The homeodomain protein IPF-1/STF-1 is expressed in a subset of islet cells and promotes rat insulin 1 gene expression dependent on an intact E1 helix-loop-helix factor binding site. Serup, P., Petersen, H.V., Pedersen, E.E., Edlund, H., Leonard, J., Petersen, J.S., Larsson, L.I., Madsen, O.D. Biochem. J. (1995)
- Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta. Shih, D.Q., Heimesaat, M., Kuwajima, S., Stein, R., Wright, C.V., Stoffel, M. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas. Apelqvist, A., Ahlgren, U., Edlund, H. Curr. Biol. (1997)
- Effects of rosiglitazone and metformin on pancreatic beta cell gene expression. Richardson, H., Campbell, S.C., Smith, S.A., Macfarlane, W.M. Diabetologia (2006)
- Retinoic acid induces Pdx1-positive endoderm in differentiating mouse embryonic stem cells. Micallef, S.J., Janes, M.E., Knezevic, K., Davis, R.P., Elefanty, A.G., Stanley, E.G. Diabetes (2005)
- Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2. Cissell, M.A., Zhao, L., Sussel, L., Henderson, E., Stein, R. J. Biol. Chem. (2003)
- Pancreatic-duodenal homeobox 1 -role in gastric endocrine patterning. Larsson, L.I., Madsen, O.D., Serup, P., Jonsson, J., Edlund, H. Mech. Dev. (1996)
- Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy. Keller, D.M., McWeeney, S., Arsenlis, A., Drouin, J., Wright, C.V., Wang, H., Wollheim, C.B., White, P., Kaestner, K.H., Goodman, R.H. J. Biol. Chem. (2007)
- Misexpression of the pancreatic homeodomain protein IDX-1 by the Hoxa-4 promoter associated with agenesis of the cecum. Heller, R.S., Stoffers, D.A., Hussain, M.A., Miller, C.P., Habener, J.F. Gastroenterology (1998)
- The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade. Jacquemin, P., Lemaigre, F.P., Rousseau, G.G. Dev. Biol. (2003)
- Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha. Song, S.Y., Gannon, M., Washington, M.K., Scoggins, C.R., Meszoely, I.M., Goldenring, J.R., Marino, C.R., Sandgren, E.P., Coffey, R.J., Wright, C.V., Leach, S.D. Gastroenterology (1999)
- Evidence for repatterning of the gastric fundic epithelium associated with Ménétrier's disease and TGFalpha overexpression. Nomura, S., Settle, S.H., Leys, C.M., Means, A.L., Peek, R.M., Leach, S.D., Wright, C.V., Coffey, R.J., Goldenring, J.R. Gastroenterology (2005)
- Negative regulation of c-Myc transcription by pancreas duodenum homeobox-1. Chen, L., Yan, H.X., Chen, J., Yang, W., Liu, Q., Zhai, B., Cao, H.F., Liu, S.Q., Wu, M.C., Wang, H.Y. Endocrinology (2007)
- Lack of TCF2/vHNF1 in mice leads to pancreas agenesis. Haumaitre, C., Barbacci, E., Jenny, M., Ott, M.O., Gradwohl, G., Cereghini, S. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner. Suzuki, R., Tobe, K., Terauchi, Y., Komeda, K., Kubota, N., Eto, K., Yamauchi, T., Azuma, K., Kaneto, H., Taguchi, T., Koga, T., German, M.S., Watada, H., Kawamori, R., Wright, C.V., Kajimoto, Y., Kimura, S., Nagai, R., Kadowaki, T. J. Biol. Chem. (2003)
- beta-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1. Li, Y., Cao, X., Li, L.X., Brubaker, P.L., Edlund, H., Drucker, D.J. Diabetes (2005)
- Endodermal expression of Nkx6 genes depends differentially on Pdx1. Pedersen, J.K., Nelson, S.B., Jorgensen, M.C., Henseleit, K.D., Fujitani, Y., Wright, C.V., Sander, M., Serup, P. Dev. Biol. (2005)
- Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes. Petersen, H.V., Serup, P., Leonard, J., Michelsen, B.K., Madsen, O.D. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding. Chakrabarti, S.K., James, J.C., Mirmira, R.G. J. Biol. Chem. (2002)
- Pdx-1 is not sufficient for repression of proglucagon gene transcription in islet or enteroendocrine cells. Flock, G., Cao, X., Drucker, D.J. Endocrinology (2005)