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Gene Review

Angptl3  -  angiopoietin-like 3

Mus musculus

Synonyms: Angiopoietin-like protein 3, Angiopoietin-related protein 3, hypl
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Disease relevance of Angptl3

  • In this study, to elucidate the role of Angptl3 in atherogenesis, we investigated the effects of hypl mutation against hyperlipidemia and atherosclerosis in apolipoprotein E knockout (apoEKO) mice [1].
  • Recently, we identified a mutation in the gene encoding angiopoietin-like protein 3 (Angptl3) in KK/San mice, and injection of adenoviruses encoding Angptl3 or recombinant ANGPTL3 protein to mutant KK/San mice raised plasma lipid levels [2].
  • Angptl3-null mice, fed a normal diet or a high-fat, high-calorie (HFC) diet, revealed markedly low plasma lipid concentrations, especially plasma triglyceride concentration, although the body weight and liver weight were not different between Angptl3-null mice and wild-type mice [3].

High impact information on Angptl3


Biological context of Angptl3


Anatomical context of Angptl3

  • Angptl3-null mice fed an HFC diet also revealed a significantly reduced epididymal adipose tissue weight despite there being no difference in adipocyte size between them and wild-type mice [3].

Associations of Angptl3 with chemical compounds

  • Taken together, the reduction of Angptl3 expression is protective against hyperlipidemia and atherosclerosis, even in the absence of apoE, owing to the enhanced catabolism and clearance of TG-rich lipoproteins [1].
  • CONCLUSIONS: Angptl3 acts as an inhibitor of EL and may be involved in the regulation of plasma HDL cholesterol and HDL-PL levels in humans and rodents [6].

Analytical, diagnostic and therapeutic context of Angptl3


  1. A decreased expression of angiopoietin-like 3 is protective against atherosclerosis in apoE-deficient mice. Ando, Y., Shimizugawa, T., Takeshita, S., Ono, M., Shimamura, M., Koishi, R., Furukawa, H. J. Lipid Res. (2003) [Pubmed]
  2. ANGPTL3 decreases very low density lipoprotein triglyceride clearance by inhibition of lipoprotein lipase. Shimizugawa, T., Ono, M., Shimamura, M., Yoshida, K., Ando, Y., Koishi, R., Ueda, K., Inaba, T., Minekura, H., Kohama, T., Furukawa, H. J. Biol. Chem. (2002) [Pubmed]
  3. Angptl3-null mice show low plasma lipid concentrations by enhanced lipoprotein lipase activity. Fujimoto, K., Koishi, R., Shimizugawa, T., Ando, Y. Exp. Anim. (2006) [Pubmed]
  4. Angptl3 regulates lipid metabolism in mice. Koishi, R., Ando, Y., Ono, M., Shimamura, M., Yasumo, H., Fujiwara, T., Horikoshi, H., Furukawa, H. Nat. Genet. (2002) [Pubmed]
  5. Locating Ath8, a locus for murine atherosclerosis susceptibility and testing several of its candidate genes in mice and humans. Korstanje, R., Eriksson, P., Samnegård, A., Olsson, P.G., Forsman-Semb, K., Sen, S., Churchill, G.A., Rollins, J., Harris, S., Hamsten, A., Paigen, B. Atherosclerosis (2004) [Pubmed]
  6. Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase. Shimamura, M., Matsuda, M., Yasumo, H., Okazaki, M., Fujimoto, K., Kono, K., Shimizugawa, T., Ando, Y., Koishi, R., Kohama, T., Sakai, N., Kotani, K., Komuro, R., Ishida, T., Hirata, K., Yamashita, S., Furukawa, H., Shimomura, I. Arterioscler. Thromb. Vasc. Biol. (2007) [Pubmed]
  7. Angiopoietin-like proteins: potential new targets for metabolic syndrome therapy. Oike, Y., Akao, M., Kubota, Y., Suda, T. Trends in molecular medicine. (2005) [Pubmed]
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