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Gene Review

Glrx3  -  glutaredoxin 3

Mus musculus

Synonyms: Glutaredoxin-3, PICOT, PKC interacting cousin of thioredoxin, PKC-interacting cousin of thioredoxin, PKC-theta-interacting protein, ...
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Disease relevance of Txnl2


High impact information on Txnl2

  • Additional proteins of unknown function were identified, such as Copine 1 and PICOT, whose developmental regulation was previously unsuspected [2].
  • The NH2 terminus, the Arg277 domain, and the N-glycosylation sites of ovine PGHS-1 are part of a large soluble, globular structure in crystalline ovine PGHS-1 (Picot, D., Loll, P. J., and Garavito, M. (1994) Nature, 367, 243-249) [3].
  • PICOT inhibits cardiac hypertrophy and enhances ventricular function and cardiomyocyte contractility [1].
  • Intracellular Ca(2+) handing analysis revealed that increases in myofilament Ca(2+) responsiveness, together with increased rate of sarcoplasmic reticulum Ca(2+) reuptake, are associated with the enhanced contractility in PICOT-overexpressing cardiomyocytes [1].
  • Adenovirus-mediated gene transfer of PICOT completely blocked the hypertrophic response of neonatal rat cardiomyocytes to enthothelin-1 and phenylephrine, as demonstrated by cell size, sarcomere rearrangement, atrial natriuretic factor expression, and rates of protein synthesis [1].

Other interactions of Txnl2

  • In addition, PICOT overexpression dramatically increased the ventricular function and cardiomyocyte contractility as measured by ejection fraction and end-systolic pressure of transgenic hearts and peak shortening of isolated cardiomyocytes, respectively [1].


  1. PICOT inhibits cardiac hypertrophy and enhances ventricular function and cardiomyocyte contractility. Jeong, D., Cha, H., Kim, E., Kang, M., Yang, D.K., Kim, J.M., Yoon, P.O., Oh, J.G., Bernecker, O.Y., Sakata, S., Le, T.T., Cui, L., Lee, Y.H., Kim, d.o. .H., Woo, S.H., Liao, R., Hajjar, R.J., Park, W.J. Circ. Res. (2006) [Pubmed]
  2. Differential protein expression at the stage of neural tube closure in the mouse embryo. Greene, N.D., Leung, K.Y., Wait, R., Begum, S., Dunn, M.J., Copp, A.J. J. Biol. Chem. (2002) [Pubmed]
  3. The orientation of prostaglandin endoperoxide synthases-1 and -2 in the endoplasmic reticulum. Otto, J.C., Smith, W.L. J. Biol. Chem. (1994) [Pubmed]
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