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Gene Review:

Kirrel - kin of IRRE like (Drosophila)

Rattus norvegicus

Synonyms: Kin of IRRE-like protein 1, Kin of irregular chiasm-like protein 1, Kirrel1, Neph1, Nephrin-like protein 1

Beall, M.H. et al.

Beall, Amidi, Gayle, Wang, Beloosesky, Ross,

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High impact information on Kirrel1

Placental and fetal membrane Nephrin and Neph1 gene expression: response to inflammation [1].
Nephrin and Neph1 are cell membrane proteins that restrict glomerular protein filtration and which are differentially expressed with renal inflammation [1].
Following maternal LPS administration, nephrin mRNA significantly increased in the membranes (0.22 +/- 0.02 to 0.51 +/- 0.050, P <.05), while Neph1 expression significantly declined in the placenta (0.19 +/- 0.05 to 0.10 +/- 0.01, P <.05) [1].

Anatomical context of Kirrel1

We sought to investigate whether nephrin and Neph1 were expressed in placenta and fetal membranes, and whether inflammation modified the expression [1].

Analytical, diagnostic and therapeutic context of Kirrel1

Placenta and fetal membranes were obtained and real-time polymerase chain reaction (PCR) performed for determination of nephrin and Neph1 levels [1].

References

Placental and fetal membrane Nephrin and Neph1 gene expression: response to inflammation. Beall, M.H., Amidi, F., Gayle, D.A., Wang, S., Beloosesky, R., Ross, M.G. J. Soc. Gynecol. Investig. (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP000218	Anopheles gambiae str. PEST
KIRREL	Bos taurus
KIRREL	Canis lupus familiaris
kirrelb	Danio rerio
kirrela	Danio rerio
rst	Drosophila melanogaster
KIRREL	Gallus gallus
KIRREL	Homo sapiens
KIRREL	Macaca mulatta
Kirrel	Mus musculus
KIRREL	Pan troglodytes
kirrel	Xenopus (Silurana) tropicalis

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