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Gene Review

KIRREL  -  kin of IRRE like (Drosophila)

Homo sapiens

Synonyms: KIRREL1, Kin of IRRE-like protein 1, Kin of irregular chiasm-like protein 1, NEPH1, Nephrin-like protein 1
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Disease relevance of KIRREL


High impact information on KIRREL


Chemical compound and disease context of KIRREL


Biological context of KIRREL


Anatomical context of KIRREL

  • RECENT FINDINGS: Nephrin and neph molecules form specialized cell junctions in various systems in different species [7].
  • Using standard stereological methods, the glomerular filtration surface area per nephron (S-Filt/neph), mesangial volume per glomerulus (V-Mes/glom), mesangial matrix volume per glomerulus (V-MM/glom) and the width of the glomerular basement membrane (GBM) were measured in nonoccluded glomeruli [8].

Associations of KIRREL with chemical compounds

  • Clinical parameters, including the duration of diabetes, urinary protein excretion and creatinine clearance were all related to S-Filt/neph, V-Mes/glom, V-MM/glom and the width of the GBM [8].

Other interactions of KIRREL


Analytical, diagnostic and therapeutic context of KIRREL

  • In 36 patient with CNI-Neph (n = 6), CAN(b) (n = 21), CAN(a) (n = 7), and others (n = 2) RAPA therapy was started 4.4-115 months (median 30.6 months) after renal transplantation [11].


  1. The carboxyl terminus of Neph family members binds to the PDZ domain protein zonula occludens-1. Huber, T.B., Schmidts, M., Gerke, P., Schermer, B., Zahn, A., Hartleben, B., Sellin, L., Walz, G., Benzing, T. J. Biol. Chem. (2003) [Pubmed]
  2. NEPH1 defines a novel family of podocin interacting proteins. Sellin, L., Huber, T.B., Gerke, P., Quack, I., Pavenstädt, H., Walz, G. FASEB J. (2003) [Pubmed]
  3. Podocyte-associated proteins FAT, alpha-actinin-4 and filtrin are expressed in Langerhans islets of the pancreas. Rinta-Valkama, J., Palmén, T., Lassila, M., Holthöfer, H. Mol. Cell. Biochem. (2007) [Pubmed]
  4. Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN. Donoviel, D.B., Freed, D.D., Vogel, H., Potter, D.G., Hawkins, E., Barrish, J.P., Mathur, B.N., Turner, C.A., Geske, R., Montgomery, C.A., Starbuck, M., Brandt, M., Gupta, A., Ramirez-Solis, R., Zambrowicz, B.P., Powell, D.R. Mol. Cell. Biol. (2001) [Pubmed]
  5. Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1. Gerke, P., Huber, T.B., Sellin, L., Benzing, T., Walz, G. J. Am. Soc. Nephrol. (2003) [Pubmed]
  6. Filtrin is a novel member of nephrin-like proteins. Ihalmo, P., Palmén, T., Ahola, H., Valtonen, E., Holthöfer, H. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  7. The slit diaphragm: a signaling platform to regulate podocyte function. Huber, T.B., Benzing, T. Curr. Opin. Nephrol. Hypertens. (2005) [Pubmed]
  8. Clinical and morphometrical interrelationships in patients with overt nephropathy induced by non-insulin-dependent diabetes mellitus. A light- and electron-microscopy study. Matsumae, T., Jimi, S., Uesugi, N., Takebayashi, S., Naito, S. Nephron (1999) [Pubmed]
  9. Analysis of the genomic structure of the porcine CD1 gene cluster. Eguchi-Ogawa, T., Morozumi, T., Tanaka, M., Shinkai, H., Okumura, N., Suzuki, K., Awata, T., Uenishi, H. Genomics (2007) [Pubmed]
  10. Clinical features and outcome of childhood minimal change nephrotic syndrome: is genetics involved? Lahdenkari, A.T., Suvanto, M., Kajantie, E., Koskimies, O., Kestilä, M., Jalanko, H. Pediatr. Nephrol. (2005) [Pubmed]
  11. Rapamycin rescue therapy in patients after kidney transplantation: first clinical experience. Weber, T., Abendroth, D., Schelzig, H. Transpl. Int. (2005) [Pubmed]
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