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Gene Review:

TrxT - Thioredoxin T

Drosophila melanogaster

Synonyms: 3315, CG3315, DmTrxT, DmelTrxT, Dmel\CG3315, ...

Maiorino, M. et al., Svensson, M.J. et al., Hozumi, A. et al.

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High impact information on TrxT

Site-directed mutagenesis of C91 in DmGPx abrogated Trx peroxidase activity, but increased the rate constant for glutathione by two orders of magnitude [1].
Molecular modeling and homology considerations based on 450 GPxs suggest peculiar features to determine Trx specificity: (i) a non-aligned second Cys within the fourth helix that acts as C(R); (ii) deletions of the subunit interfaces typical of tetrameric GPxs leading to flexibility of the C(R)-containing loop [1].
TrxT and dhd are arranged as a gene pair, transcribed in opposite directions and sharing a 471 bp regulatory region [2].
Use of a transgenic construct expressing TrxT fused to Enhanced Yellow Fluorescent Protein reveals a clear association of TrxT with the Y chromosome lampbrush loops ks-1 and kl-5 in primary spermatocytes [2].
Both TrxT and DHD proteins are localized within the nuclei in testes and ovaries, respectively [2].

Anatomical context of TrxT

Among the five ICs in Ciona, three are orthologs of those in sea urchin dynein: two are WD-repeat proteins and the third one, unique to metazoan sperm flagella, contains both thioredoxin and nucleoside diphosphate kinase modules [3].

References

The Thioredoxin Specificity of Drosophila GPx: A Paradigm for a Peroxiredoxin-like Mechanism of many Glutathione Peroxidases. Maiorino, M., Ursini, F., Bosello, V., Toppo, S., Tosatto, S.C., Mauri, P., Becker, K., Roveri, A., Bulato, C., Benazzi, L., De Palma, A., Floh??, L. J. Mol. Biol. (2007) [Pubmed]
The ThioredoxinT and deadhead gene pair encode testis- and ovary-specific thioredoxins in Drosophila melanogaster. Svensson, M.J., Chen, J.D., Pirrotta, V., Larsson, J. Chromosoma (2003) [Pubmed]
Molecular characterization of Ciona sperm outer arm dynein reveals multiple components related to outer arm docking complex protein 2. Hozumi, A., Satouh, Y., Makino, Y., Toda, T., Ide, H., Ogawa, K., King, S.M., Inaba, K. Cell Motil. Cytoskeleton (2006) [Pubmed]

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