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Gene Review

rux  -  roughex

Drosophila melanogaster

Synonyms: CG4336, Cell cycle negative regulator roughex, Dmel\CG4336, Rux
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High impact information on rux


Biological context of rux


Physical interactions of rux

  • Results: Rux interacted with CycA and CycB in coprecipitation experiments [7].

Regulatory relationships of rux

  • The roughex gene product plays a key role in this synchronization by negatively regulating cyclin A protein levels in G(1) [4].

Other interactions of rux


  1. roughex is a dose-dependent regulator of the second meiotic division during Drosophila spermatogenesis. Gönczy, P., Thomas, B.J., DiNardo, S. Cell (1994) [Pubmed]
  2. Cell cycle progression in the developing Drosophila eye: roughex encodes a novel protein required for the establishment of G1. Thomas, B.J., Gunning, D.A., Cho, J., Zipursky, L. Cell (1994) [Pubmed]
  3. The cyclin-dependent kinase inhibitor Roughex is involved in mitotic exit in Drosophila. Foley, E., Sprenger, F. Curr. Biol. (2001) [Pubmed]
  4. Roughex mediates G(1) arrest through a physical association with cyclin A. Avedisov, S.N., Krasnoselskaya, I., Mortin, M., Thomas, B.J. Mol. Cell. Biol. (2000) [Pubmed]
  5. Control of G1 in the developing Drosophila eye: rca1 regulates Cyclin A. Dong, X., Zavitz, K.H., Thomas, B.J., Lin, M., Campbell, S., Zipursky, S.L. Genes Dev. (1997) [Pubmed]
  6. roughex down-regulates G2 cyclins in G1. Thomas, B.J., Zavitz, K.H., Dong, X., Lane, M.E., Weigmann, K., Finley, R.L., Brent, R., Lehner, C.F., Zipursky, S.L. Genes Dev. (1997) [Pubmed]
  7. Rux is a cyclin-dependent kinase inhibitor (CKI) specific for mitotic cyclin-Cdk complexes. Foley, E., O'Farrell, P.H., Sprenger, F. Curr. Biol. (1999) [Pubmed]
  8. Sister chromatids fail to separate during an induced endoreplication cycle in Drosophila embryos. Vidwans, S.J., DiGregorio, P.J., Shermoen, A.W., Foat, B., Iwasa, J., Yakubovich, N., O'Farrell, P.H. Curr. Biol. (2002) [Pubmed]
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