Gene Review:
Traf6 - TNF receptor-associated factor 6
Mus musculus
Synonyms:
2310003F17Rik, AI851288, C630032O20Rik, E3 ubiquitin-protein ligase TRAF6
- TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Lomaga, M.A., Yeh, W.C., Sarosi, I., Duncan, G.S., Furlonger, C., Ho, A., Morony, S., Capparelli, C., Van, G., Kaufman, S., van der Heiden, A., Itie, A., Wakeham, A., Khoo, W., Sasaki, T., Cao, Z., Penninger, J.M., Paige, C.J., Lacey, D.L., Dunstan, C.R., Boyle, W.J., Goeddel, D.V., Mak, T.W. Genes Dev. (1999)
- Genomic profiling of kidney ischemia-reperfusion reveals expression of specific alloimmunity-associated genes: linking "immune" and "nonimmune" injury events. Grigoryev, D.N., Liu, M., Cheadle, C., Barnes, K.C., Rabb, H. Transplant. Proc. (2006)
- Distinct molecular mechanism for initiating TRAF6 signalling. Ye, H., Arron, J.R., Lamothe, B., Cirilli, M., Kobayashi, T., Shevde, N.K., Segal, D., Dzivenu, O.K., Vologodskaia, M., Yim, M., Du, K., Singh, S., Pike, J.W., Darnay, B.G., Choi, Y., Wu, H. Nature (2002)
- FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner. Bai, S., Kitaura, H., Zhao, H., Chen, J., Müller, J.M., Schüle, R., Darnay, B., Novack, D.V., Ross, F.P., Teitelbaum, S.L. J. Clin. Invest. (2005)
- Site-specific Lys-63-linked Tumor Necrosis Factor Receptor-associated Factor 6 Auto-ubiquitination Is a Critical Determinant of I{kappa}B Kinase Activation. Lamothe, B., Besse, A., Campos, A.D., Webster, W.K., Wu, H., Darnay, B.G. J. Biol. Chem. (2007)
- Involvement of TNF receptor-associated factor 6 in IL-25 receptor signaling. Maezawa, Y., Nakajima, H., Suzuki, K., Tamachi, T., Ikeda, K., Inoue, J., Saito, Y., Iwamoto, I. J. Immunol. (2006)
- Traf6 is essential for murine tooth cusp morphogenesis. Ohazama, A., Courtney, J.M., Tucker, A.S., Naito, A., Tanaka, S., Inoue, J., Sharpe, P.T. Dev. Dyn. (2004)
- TNF-receptor associated factor 6-deficient fibroblast is sensitive to the TNF-alpha-induced cell death: Involvement of reactive oxygen species. Ichikawa, D., Funakoshi-Tago, M., Aizu-Yokota, E., Sonoda, Y., Inoue, J., Kasahara, T. Biochem. Biophys. Res. Commun. (2006)
- Suppressors of cytokine signaling-1 and -3 regulate osteoclastogenesis in the presence of inflammatory cytokines. Ohishi, M., Matsumura, Y., Aki, D., Mashima, R., Taniguchi, K., Kobayashi, T., Kukita, T., Iwamoto, Y., Yoshimura, A. J. Immunol. (2005)
- Expression of TNF-receptor-associated factor genes in murine tooth development. Ohazama, A., Courtney, J.M., Sharpe, P.T. Gene Expr. Patterns (2003)
- TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alpha. Andrade, R.M., Wessendarp, M., Portillo, J.A., Yang, J.Q., Gomez, F.J., Durbin, J.E., Bishop, G.A., Subauste, C.S. J. Immunol. (2005)
- IL-1 regulates cytoskeletal organization in osteoclasts via TNF receptor-associated factor 6/c-Src complex. Nakamura, I., Kadono, Y., Takayanagi, H., Jimi, E., Miyazaki, T., Oda, H., Nakamura, K., Tanaka, S., Rodan, G.A., Duong, l.e. .T. J. Immunol. (2002)
