The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Traf6  -  TNF receptor-associated factor 6

Mus musculus

Synonyms: 2310003F17Rik, AI851288, C630032O20Rik, E3 ubiquitin-protein ligase TRAF6
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Traf6

  • TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling [1].
  • GO analysis identified 10 and 17 alloimmunity-related genes affected by IRI induced by 30 and 60 minutes of ischemia, respectively, including Traf6 (FC = 2.99) and H2-D1 (FC = 2.58) [2].

High impact information on Traf6


Biological context of Traf6


Anatomical context of Traf6


Physical interactions of Traf6


Other interactions of Traf6

  • FHL2 is, therefore, an antiosteoclastogenic molecule exerting its effect by attenuating TRAF6-mediated RANK signaling [4].


  1. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Lomaga, M.A., Yeh, W.C., Sarosi, I., Duncan, G.S., Furlonger, C., Ho, A., Morony, S., Capparelli, C., Van, G., Kaufman, S., van der Heiden, A., Itie, A., Wakeham, A., Khoo, W., Sasaki, T., Cao, Z., Penninger, J.M., Paige, C.J., Lacey, D.L., Dunstan, C.R., Boyle, W.J., Goeddel, D.V., Mak, T.W. Genes Dev. (1999) [Pubmed]
  2. Genomic profiling of kidney ischemia-reperfusion reveals expression of specific alloimmunity-associated genes: linking "immune" and "nonimmune" injury events. Grigoryev, D.N., Liu, M., Cheadle, C., Barnes, K.C., Rabb, H. Transplant. Proc. (2006) [Pubmed]
  3. Distinct molecular mechanism for initiating TRAF6 signalling. Ye, H., Arron, J.R., Lamothe, B., Cirilli, M., Kobayashi, T., Shevde, N.K., Segal, D., Dzivenu, O.K., Vologodskaia, M., Yim, M., Du, K., Singh, S., Pike, J.W., Darnay, B.G., Choi, Y., Wu, H. Nature (2002) [Pubmed]
  4. FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner. Bai, S., Kitaura, H., Zhao, H., Chen, J., Müller, J.M., Schüle, R., Darnay, B., Novack, D.V., Ross, F.P., Teitelbaum, S.L. J. Clin. Invest. (2005) [Pubmed]
  5. Site-specific Lys-63-linked Tumor Necrosis Factor Receptor-associated Factor 6 Auto-ubiquitination Is a Critical Determinant of I{kappa}B Kinase Activation. Lamothe, B., Besse, A., Campos, A.D., Webster, W.K., Wu, H., Darnay, B.G. J. Biol. Chem. (2007) [Pubmed]
  6. Involvement of TNF receptor-associated factor 6 in IL-25 receptor signaling. Maezawa, Y., Nakajima, H., Suzuki, K., Tamachi, T., Ikeda, K., Inoue, J., Saito, Y., Iwamoto, I. J. Immunol. (2006) [Pubmed]
  7. Traf6 is essential for murine tooth cusp morphogenesis. Ohazama, A., Courtney, J.M., Tucker, A.S., Naito, A., Tanaka, S., Inoue, J., Sharpe, P.T. Dev. Dyn. (2004) [Pubmed]
  8. TNF-receptor associated factor 6-deficient fibroblast is sensitive to the TNF-alpha-induced cell death: Involvement of reactive oxygen species. Ichikawa, D., Funakoshi-Tago, M., Aizu-Yokota, E., Sonoda, Y., Inoue, J., Kasahara, T. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  9. Suppressors of cytokine signaling-1 and -3 regulate osteoclastogenesis in the presence of inflammatory cytokines. Ohishi, M., Matsumura, Y., Aki, D., Mashima, R., Taniguchi, K., Kobayashi, T., Kukita, T., Iwamoto, Y., Yoshimura, A. J. Immunol. (2005) [Pubmed]
  10. Expression of TNF-receptor-associated factor genes in murine tooth development. Ohazama, A., Courtney, J.M., Sharpe, P.T. Gene Expr. Patterns (2003) [Pubmed]
  11. TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alpha. Andrade, R.M., Wessendarp, M., Portillo, J.A., Yang, J.Q., Gomez, F.J., Durbin, J.E., Bishop, G.A., Subauste, C.S. J. Immunol. (2005) [Pubmed]
  12. IL-1 regulates cytoskeletal organization in osteoclasts via TNF receptor-associated factor 6/c-Src complex. Nakamura, I., Kadono, Y., Takayanagi, H., Jimi, E., Miyazaki, T., Oda, H., Nakamura, K., Tanaka, S., Rodan, G.A., Duong, l.e. .T. J. Immunol. (2002) [Pubmed]
WikiGenes - Universities