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Gene Review

Traf4  -  TNF-receptor-associated factor 4

Drosophila melanogaster

Synonyms: CG3048, DTRAF, DTRAF1, Dmel\CG3048, TRAF, ...
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Disease relevance of Traf1


High impact information on Traf1


Biological context of Traf1


Anatomical context of Traf1

  • Interestingly, though Pelle and DTRAF1 individually were unable to induce NFkappaB in a human cell line, co-expression of Pelle and DTRAF1 resulted in significant NFkappaB activity [6].
  • DTRAF1 is most closely related to mammalian TRAF4 which is predominantly expressed during nervous system development and in ephitelial progenitor cells [5].
  • In vertebrates, TRAF proteins link these pathways also to IL-1R-related molecules and members of the TNF receptor superfamily, which orchestrate a variety of immunoregulatory processes of the innate but also of the adaptive immune system [7].

Associations of Traf1 with chemical compounds

  • Our data suggest that DTRAF1 binds to Baz and acts downstream of Egr in the Mira/Pros telophase rescue pathway [3].

Regulatory relationships of Traf1

  • In Drosophila, DTRAF1 is thus a good candidate for an upstream molecule that regulates the JNK pathway by interacting with, and activating, Msn [8].

Other interactions of Traf1


  1. The Drosophila Inhibitor of Apoptosis Protein DIAP2 Functions in Innate Immunity and Is Essential To Resist Gram-Negative Bacterial Infection. Leulier, F., Lhocine, N., Lemaitre, B., Meier, P. Mol. Cell. Biol. (2006) [Pubmed]
  2. Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila. Kuranaga, E., Kanuka, H., Igaki, T., Sawamoto, K., Ichijo, H., Okano, H., Miura, M. Nat. Cell Biol. (2002) [Pubmed]
  3. Drosophila homologs of mammalian TNF/TNFR-related molecules regulate segregation of Miranda/Prospero in neuroblasts. Wang, H., Cai, Y., Chia, W., Yang, X. EMBO J. (2006) [Pubmed]
  4. Discrete functions of TRAF1 and TRAF2 in Drosophila melanogaster mediated by c-Jun N-terminal kinase and NF-kappaB-dependent signaling pathways. Cha, G.H., Cho, K.S., Lee, J.H., Kim, M., Kim, E., Park, J., Lee, S.B., Chung, J. Mol. Cell. Biol. (2003) [Pubmed]
  5. Dynamic expression of Drosophila TRAF1 during embryogenesis and larval development. Preiss, A., Johannes, B., Nagel, A.C., Maier, D., Peters, N., Wajant, H. Mech. Dev. (2001) [Pubmed]
  6. The Drosophila tumor necrosis factor receptor-associated factor-1 (DTRAF1) interacts with Pelle and regulates NFkappaB activity. Zapata, J.M., Matsuzawa, S., Godzik, A., Leo, E., Wasserman, S.A., Reed, J.C. J. Biol. Chem. (2000) [Pubmed]
  7. Analogies between Drosophila and mammalian TRAF pathways. Wajant, H., Scheurich, P. Prog. Mol. Subcell. Biol. (2004) [Pubmed]
  8. A Drosophila TNF-receptor-associated factor (TRAF) binds the ste20 kinase Misshapen and activates Jun kinase. Liu, H., Su, Y.C., Becker, E., Treisman, J., Skolnik, E.Y. Curr. Biol. (1999) [Pubmed]
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