Gene Review:
Gsc - goosecoid homeobox
Rattus norvegicus
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High impact information on Gsc
- In contrast, expression of the bHLH transcription factor HES-1 repressed goosecoid-mediated neurite outgrowth without changing the proportion of S-phase cells [1].
- Expression of goosecoid led to a decrease in the percentage of S-phase cells and to upregulation of the expression of the neuron-specific markers MAP-1b and neurofilament-L [1].
- To investigate the role of goosecoid in neuronal differentiation of mammalian cells, we have introduced goosecoid into PC12 cells [1].
- In all vertebrate species, the homeobox gene goosecoid serves as a marker of the Spemann organizer tissue [1].
- Expression of goosecoid resulted in reduced cell proliferation and enhanced neurite outgrowth in response to NGF [1].
Biological context of Gsc
- These results suggest that goosecoid is involved in neuronal differentiation in two ways, by slowing the cell cycle and stimulating neurite outgrowth, and that these two events are separately regulated [1].
References
- Goosecoid suppresses cell growth and enhances neuronal differentiation of PC12 cells. Sawada, K., Konishi, Y., Tominaga, M., Watanabe, Y., Hirano, J., Inoue, S., Kageyama, R., Blum, M., Tominaga, A. J. Cell. Sci. (2000) [Pubmed]
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