Psychiatry related information on Lsd-2

• The Perilipin homologue LSD2 has been identified as a regulator of microtubule motor activity in Drosophila embryos [1].

High impact information on Lsd-2

• Furthermore, we show that the accumulation of activated Akt in the cytoplasm is responsible for this phenotype and leads to a much higher expression of LSD2, the fly homologue of the vertebrate lipid-storage protein perilipin [2].
• In addition, the demonstration that LSD2 regulates both transport and lipid metabolism suggests a link between lipid-droplet motion and lipid homeostasis [3].
• Similar to its mammalian counterpart Perilipin, LSD2 is responsible for regulating lipid homeostasis [3].
• We find that lack of LSD2 causes a specific transport defect: Droplet distribution fails to undergo the dramatic changes characteristic of the wild-type [3].
• Microtubule motors: LSD2 trips the toggle [1].

Biological context of Lsd-2

• We examined the function of Lsd2, one of only two PAT domain-encoding genes in the Drosophila genome [4].
• We have generated an Lsd2 mutant and described its phenotype [5].
• Consistent with its expression in the female germ line, we showed that Lsd2 is a maternal effect gene that is required for normal embryogenesis [5].

Anatomical context of Lsd-2

• Lsd-2 is expressed in fat bodies and in the female germ line and is involved in lipid storage in these tissues [6].
• We showed that Lsd2 is predominantly expressed in tissues engaged in high levels of lipid metabolism, the fat body and the germ line of females [5].

References