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Gene Review

Lsd-2  -  Lipid storage droplet-2

Drosophila melanogaster

Synonyms: 145098_at, CG9057, DmPLIN2, Dmel\CG9057, LSD-2, ...
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Psychiatry related information on Lsd-2


High impact information on Lsd-2

  • Furthermore, we show that the accumulation of activated Akt in the cytoplasm is responsible for this phenotype and leads to a much higher expression of LSD2, the fly homologue of the vertebrate lipid-storage protein perilipin [2].
  • In addition, the demonstration that LSD2 regulates both transport and lipid metabolism suggests a link between lipid-droplet motion and lipid homeostasis [3].
  • Similar to its mammalian counterpart Perilipin, LSD2 is responsible for regulating lipid homeostasis [3].
  • We find that lack of LSD2 causes a specific transport defect: Droplet distribution fails to undergo the dramatic changes characteristic of the wild-type [3].
  • Microtubule motors: LSD2 trips the toggle [1].

Biological context of Lsd-2

  • We examined the function of Lsd2, one of only two PAT domain-encoding genes in the Drosophila genome [4].
  • We have generated an Lsd2 mutant and described its phenotype [5].
  • Consistent with its expression in the female germ line, we showed that Lsd2 is a maternal effect gene that is required for normal embryogenesis [5].

Anatomical context of Lsd-2


  1. Microtubule motors: LSD2 trips the toggle. Cohen, R.S. Curr. Biol. (2005) [Pubmed]
  2. Cytoplasmic activated protein kinase Akt regulates lipid-droplet accumulation in Drosophila nurse cells. Vereshchagina, N., Wilson, C. Development (2006) [Pubmed]
  3. Regulation of lipid-droplet transport by the perilipin homolog LSD2. Welte, M.A., Cermelli, S., Griner, J., Viera, A., Guo, Y., Kim, D.H., Gindhart, J.G., Gross, S.P. Curr. Biol. (2005) [Pubmed]
  4. Control of fat storage by a Drosophila PAT domain protein. Grönke, S., Beller, M., Fellert, S., Ramakrishnan, H., Jäckle, H., Kühnlein, R.P. Curr. Biol. (2003) [Pubmed]
  5. Drosophila Perilipin/ADRP homologue Lsd2 regulates lipid metabolism. Teixeira, L., Rabouille, C., Rørth, P., Ephrussi, A., Vanzo, N.F. Mech. Dev. (2003) [Pubmed]
  6. Drosophila Lipid Storage Droplet 2 gene (Lsd-2) is expressed and controls lipid storage in wing imaginal discs. Fauny, J.D., Silber, J., Zider, A. Dev. Dyn. (2005) [Pubmed]
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