Gene Review:
Akt1 - CG4006 gene product from transcript CG4006-RE
Drosophila melanogaster
Synonyms:
AKT, AKT/PKB, AKT1, Akt, Akt/PKB, ...
- The cytohesin Steppke is essential for insulin signalling in Drosophila. Fuss, B., Becker, T., Zinke, I., Hoch, M. Nature (2006)
- Tsc2 is not a critical target of Akt during normal Drosophila development. Dong, J., Pan, D. Genes Dev. (2004)
- Genetic analysis of protein kinase B (AKT) in Drosophila. Staveley, B.E., Ruel, L., Jin, J., Stambolic, V., Mastronardi, F.G., Heitzler, P., Woodgett, J.R., Manoukian, A.S. Curr. Biol. (1998)
- Phosphatidylinositol 3-kinase and Akt nonautonomously promote perineurial glial growth in Drosophila peripheral nerves. Lavery, W., Hall, V., Yager, J.C., Rottgers, A., Wells, M.C., Stern, M. J. Neurosci. (2007)
- Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth. Hietakangas, V., Cohen, S.M. Genes Dev. (2007)
- The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila. Reiling, J.H., Hafen, E. Genes Dev. (2004)
- Akt regulates growth by directly phosphorylating Tsc2. Potter, C.J., Pedraza, L.G., Xu, T. Nat. Cell Biol. (2002)
- 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. Alessi, D.R., Deak, M., Casamayor, A., Caudwell, F.B., Morrice, N., Norman, D.G., Gaffney, P., Reese, C.B., MacDougall, C.N., Harbison, D., Ashworth, A., Bownes, M. Curr. Biol. (1997)
- The SH2-like Akt homology (AH) domain of c-akt is present in multiple copies in the genome of vertebrate and invertebrate eucaryotes. Cloning and characterization of the Drosophila melanogaster c-akt homolog Dakt1. Franke, T.F., Tartof, K.D., Tsichlis, P.N. Oncogene (1994)
- Regulated and polarized PtdIns(3,4,5)P3 accumulation is essential for apical membrane morphogenesis in photoreceptor epithelial cells. Pinal, N., Goberdhan, D.C., Collinson, L., Fujita, Y., Cox, I.M., Wilson, C., Pichaud, F. Curr. Biol. (2006)
- Proteasomal degradation of the FoxO1 transcriptional regulator in cells transformed by the P3k and Akt oncoproteins. Aoki, M., Jiang, H., Vogt, P.K. Proc. Natl. Acad. Sci. U.S.A. (2004)
- FOXO-independent suppression of programmed cell death by the PI3K/Akt signaling pathway in Drosophila. Liu, Y., Lehmann, M. Dev. Genes Evol. (2006)
- The Akt of translational control. Ruggero, D., Sonenberg, N. Oncogene (2005)
- Mutations of the PH domain of protein kinase B (PKB/AKT) are absent in human epidermal skin tumors. Waldmann, V., Wacker, J. Dermatology (Basel) (2001)
- Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B. Lizcano, J.M., Alrubaie, S., Kieloch, A., Deak, M., Leevers, S.J., Alessi, D.R. Biochem. J. (2003)
- Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB. Verdu, J., Buratovich, M.A., Wilder, E.L., Birnbaum, M.J. Nat. Cell Biol. (1999)
- Drosophila PI3 kinase and Akt involved in insulin-stimulated proliferation and ERK pathway activation in Schneider cells. Kim, S.E., Cho, J.Y., Kim, K.S., Lee, S.J., Lee, K.H., Choi, K.Y. Cell. Signal. (2004)
- Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling. Yang, Y., Gehrke, S., Haque, M.E., Imai, Y., Kosek, J., Yang, L., Beal, M.F., Nishimura, I., Wakamatsu, K., Ito, S., Takahashi, R., Lu, B. Proc. Natl. Acad. Sci. U.S.A. (2005)
- The protein phosphatase PP2A-B' subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism in Drosophila. Vereshchagina, N., Ramel, M.C., Bitoun, E., Wilson, C. J. Cell. Sci. (2008)
- PDK1 regulates growth through Akt and S6K in Drosophila. Rintelen, F., Stocker, H., Thomas, G., Hafen, E. Proc. Natl. Acad. Sci. U.S.A. (2001)
- The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila. Scanga, S.E., Ruel, L., Binari, R.C., Snow, B., Stambolic, V., Bouchard, D., Peters, M., Calvieri, B., Mak, T.W., Woodgett, J.R., Manoukian, A.S. Oncogene (2000)
- Akt and foxo Dysregulation Contribute to Infection-Induced Wasting in Drosophila. Dionne, M.S., Pham, L.N., Shirasu-Hiza, M., Schneider, D.S. Curr. Biol. (2006)
- Drosophila phosphoinositide-dependent kinase-1 regulates apoptosis and growth via the phosphoinositide 3-kinase-dependent signaling pathway. Cho, K.S., Lee, J.H., Kim, S., Kim, D., Koh, H., Lee, J., Kim, C., Kim, J., Chung, J. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways. Clemens, J.C., Worby, C.A., Simonson-Leff, N., Muda, M., Maehama, T., Hemmings, B.A., Dixon, J.E. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Tuberous sclerosis: from tubers to mTOR. Kwiatkowski, D.J. Ann. Hum. Genet. (2003)
- Trachealess--a new transcription factor target for PKB/Akt. Downward, J., Leevers, S.J. Dev. Cell (2001)