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Gene Review

PGRP-LE  -  Peptidoglycan recognition protein LE

Drosophila melanogaster

Synonyms: CG8995, Dmel\CG8995, PGRP, Peptidoglycan-recognition protein LE, anon-WO0153538.66, ...
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Disease relevance of PGRP-LE


High impact information on PGRP-LE

  • Here we show that full-length PGRP-LE acted as an intracellular receptor for monomeric peptidoglycan, whereas a version of PGRP-LE containing only the PGRP domain functioned extracellularly, like the mammalian CD14 molecule, to enhance PGRP-LC-mediated peptidoglycan recognition on the cell surface [1].
  • Consistent with this, PGRP-LE binds to the diaminopimelic acid-type peptidoglycan, a cell-wall component of the bacteria capable of activating the imd pathway, but not to the lysine-type peptidoglycan [2].
  • Therefore, PGRP-LE acts as a pattern-recognition receptor to the diaminopimelic acid-type peptidoglycan and activates both the proteolytic cascade and intracellular signaling in Drosophila immunity [2].
  • Moreover, PGRP-LE activates the prophenoloxidase cascade, a proteolytic cascade in the hemolymph [2].
  • Unexpectedly, TCT induces infinite head-to-tail dimerization of PGRP-LE, in which the disaccharide moiety, but not the peptide stem, of TCT is positioned at the dimer interface [3].

Biological context of PGRP-LE


  1. PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan. Kaneko, T., Yano, T., Aggarwal, K., Lim, J.H., Ueda, K., Oshima, Y., Peach, C., Erturk-Hasdemir, D., Goldman, W.E., Oh, B.H., Kurata, S., Silverman, N. Nat. Immunol. (2006) [Pubmed]
  2. Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae. Takehana, A., Katsuyama, T., Yano, T., Oshima, Y., Takada, H., Aigaki, T., Kurata, S. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Structural basis for preferential recognition of diaminopimelic acid-type peptidoglycan by a subset of peptidoglycan recognition proteins. Lim, J.H., Kim, M.S., Kim, H.E., Yano, T., Oshima, Y., Aggarwal, K., Goldman, W.E., Silverman, N., Kurata, S., Oh, B.H. J. Biol. Chem. (2006) [Pubmed]
  4. Trade-offs between longevity and pathogen resistance in Drosophila melanogaster are mediated by NFkappaB signaling. Libert, S., Chao, Y., Chu, X., Pletcher, S.D. Aging Cell (2006) [Pubmed]
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