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Gene Review

PGRP-LC  -  Peptidoglycan recognition protein LC

Drosophila melanogaster

Synonyms: (PGRP)-LC, CG4432, Dm PGRP-LC, Dmel\CG4432, Immune response deficient 7 protein, ...
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Disease relevance of PGRP-LC


High impact information on PGRP-LC


Biological context of PGRP-LC


Anatomical context of PGRP-LC

  • In this study, we have further analyzed the specific PG molecular requirements for Imd activation through the pattern recognition receptor PGRP-LC in both cultured cell line and in flies [8].

Physical interactions of PGRP-LC

  • The presence of a defective peptidoglycan-docking groove, while preserving a unique role in mediating monomeric peptidoglycan induction of immune response, suggests that PGRP-LCa recognizes the exposed structural features of a monomeric muropeptide when the latter is bound to and presented by the ectodomain of PGRP-LCx [9].

Other interactions of PGRP-LC

  • PGRP-LCx, the default peptidoglycan receptor of the Imd/Relish pathway, has strong affinity for all polymeric peptidoglycans tested and for monomeric peptidoglycan [10].
  • The crystal structure at 2.1 angstrom resolution of TCT in complex with the ectodomains of PGRP-LCa and PGRP-LCx shows that TCT is bound to and presented by the LCx ectodomain for recognition by the LCa ectodomain; the latter lacks a canonical peptidoglycan-docking groove conserved in other PGRPs [11].


  1. Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli. Rämet, M., Manfruelli, P., Pearson, A., Mathey-Prevot, B., Ezekowitz, R.A. Nature (2002) [Pubmed]
  2. The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein. Gottar, M., Gobert, V., Michel, T., Belvin, M., Duyk, G., Hoffmann, J.A., Ferrandon, D., Royet, J. Nature (2002) [Pubmed]
  3. Intra- and extracellular recognition of pathogens and activation of innate immunity. Kurata, S. Yakugaku Zasshi (2006) [Pubmed]
  4. Monomeric and polymeric gram-negative peptidoglycan but not purified LPS stimulate the Drosophila IMD pathway. Kaneko, T., Goldman, W.E., Mellroth, P., Steiner, H., Fukase, K., Kusumoto, S., Harley, W., Fox, A., Golenbock, D., Silverman, N. Immunity (2004) [Pubmed]
  5. PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan. Kaneko, T., Yano, T., Aggarwal, K., Lim, J.H., Ueda, K., Oshima, Y., Peach, C., Erturk-Hasdemir, D., Goldman, W.E., Oh, B.H., Kurata, S., Silverman, N. Nat. Immunol. (2006) [Pubmed]
  6. Drosophila peptidoglycan recognition protein LC (PGRP-LC) acts as a signal-transducing innate immune receptor. Choe, K.M., Lee, H., Anderson, K.V. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  7. Functional diversity of the Drosophila PGRP-LC gene cluster in the response to lipopolysaccharide and peptidoglycan. Werner, T., Borge-Renberg, K., Mellroth, P., Steiner, H., Hultmark, D. J. Biol. Chem. (2003) [Pubmed]
  8. Peptidoglycan molecular requirements allowing detection by the Drosophila immune deficiency pathway. Stenbak, C.R., Ryu, J.H., Leulier, F., Pili-Floury, S., Parquet, C., Hervé, M., Chaput, C., Boneca, I.G., Lee, W.J., Lemaitre, B., Mengin-Lecreulx, D. J. Immunol. (2004) [Pubmed]
  9. Structure of the ectodomain of Drosophila peptidoglycan-recognition protein LCa suggests a molecular mechanism for pattern recognition. Chang, C.I., Ihara, K., Chelliah, Y., Mengin-Lecreulx, D., Wakatsuki, S., Deisenhofer, J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  10. Ligand-induced dimerization of Drosophila peptidoglycan recognition proteins in vitro. Mellroth, P., Karlsson, J., Håkansson, J., Schultz, N., Goldman, W.E., Steiner, H. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  11. Structure of tracheal cytotoxin in complex with a heterodimeric pattern-recognition receptor. Chang, C.I., Chelliah, Y., Borek, D., Mengin-Lecreulx, D., Deisenhofer, J. Science (2006) [Pubmed]
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