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Gene Review

IRGM  -  immunity-related GTPase family, M

Homo sapiens

Synonyms: IFI1, IRGM1, Immunity-related GTPase family M protein, Immunity-related GTPase family M protein 1, Interferon-inducible protein 1, ...
 
 
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Disease relevance of IRGM

 

High impact information on IRGM

  • Induction of autophagy by physiological, pharmacological or immunological signals, including the major antituberculosis Th1 cytokine IFN-gamma and its downstream effector p47 GTPase LRG-47, can overcome mycobacterial phagosome maturation block and inhibit intracellular M. tuberculosis survival [3].
  • Human IRGM induces autophagy to eliminate intracellular mycobacteria [2].

References

  1. A novel extended-spectrum beta-lactamase CTX-M-23 with a P167T substitution in the active-site omega loop associated with ceftazidime resistance. Stürenburg, E., Kühn, A., Mack, D., Laufs, R. J. Antimicrob. Chemother. (2004) [Pubmed]
  2. Human IRGM induces autophagy to eliminate intracellular mycobacteria. Singh, S.B., Davis, A.S., Taylor, G.A., Deretic, V. Science (2006) [Pubmed]
  3. Mycobacterium tuberculosis inhibition of phagolysosome biogenesis and autophagy as a host defence mechanism. Deretic, V., Singh, S., Master, S., Harris, J., Roberts, E., Kyei, G., Davis, A., de Haro, S., Naylor, J., Lee, H.H., Vergne, I. Cell. Microbiol. (2006) [Pubmed]
 
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