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Gene Review

Pkd2  -  Polycystic kidney disease 2 ortholog (H....

Drosophila melanogaster

Synonyms: AMO, Amo, CG6504, Dmel\CG6504, Dmpkd2, ...
 
 
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Disease relevance of Pkd2

 

High impact information on Pkd2

  • The effect of Pkd2 mutations alone on the skeletal muscle was minimal but was exacerbated by ryanodine-induced perturbation of intracellular Ca(2+) stores [3].
  • Drosophila Pkd2 is haploid-insufficient for mediating optimal smooth muscle contractility [3].
  • These results suggest that PKD2 cooperates with the ryanodine receptor to promote optimal muscle contractility through intracellular Ca(2+) homeostasis [3].
  • The finding that Amo functions in sperm flagella supports a common and evolutionarily conserved role for polycystin-2 proteins in both motile and nonmotile axonemal-containing structures [2].
  • In agreement with this structural information, expression of PC2 in Xenopus oocytes or reconstitution of human PC2 in planar lipid bilayers produced Ca(2+)-activated cation channels [4].
 

Anatomical context of Pkd2

References

  1. PKD2 cation channel is required for directional sperm movement and male fertility. Gao, Z., Ruden, D.M., Lu, X. Curr. Biol. (2003) [Pubmed]
  2. A flagellar polycystin-2 homolog required for male fertility in Drosophila. Watnick, T.J., Jin, Y., Matunis, E., Kernan, M.J., Montell, C. Curr. Biol. (2003) [Pubmed]
  3. Drosophila Pkd2 is haploid-insufficient for mediating optimal smooth muscle contractility. Gao, Z., Joseph, E., Ruden, D.M., Lu, X. J. Biol. Chem. (2004) [Pubmed]
  4. Evolutionary conservation of Drosophila polycystin-2 as a calcium-activated cation channel. Venglarik, C.J., Gao, Z., Lu, X. J. Am. Soc. Nephrol. (2004) [Pubmed]
 
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