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Gene Review

Orc5  -  Origin recognition complex subunit 5

Drosophila melanogaster

Synonyms: BG:DS00941.8, CG7833, D-orc5, DmORC5, DmOrc5, ...
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High impact information on Orc5

  • The six-subunit origin recognition complex (ORC) is a DNA replication initiator protein in eukaryotes that defines the localization of the origins of replication [1].
  • We report here that the smallest Drosophila ORC subunit, Orc6, is a DNA binding protein that is necessary for the DNA binding and DNA replication functions of ORC [1].
  • RT-PCR analyses of RNA purified from E2f2 mutant follicle cells indicate an increase in the level of Orc5 mRNA relative to wild type [2].
  • A second divergent promoter region (P2) controls the expression of the orc5 and sop2 genes [3].
  • Its role in controlling the expression of the pol gamma-beta and orc5 genes establishes a common regulatory mechanism linking nuclear and mitochondrial DNA replication [3].

Biological context of Orc5

  • We propose that the abnormal subcellular distribution and segregation of ORC proteins in AD might compromise their physiological function in gene silencing and plasticity [4].
  • ORC subunits might, thus, provide a direct molecular link between synaptic plasticity, DNA replication and cell death [4].
  • ORC subunits in the mammalian brain and their homologes in Drosophila, however, have further been implicated in the regulation of structural neuronal plasticity and cognitive function [4].


  1. Role of the Orc6 Protein in Origin Recognition Complex-Dependent DNA Binding and Replication in Drosophila melanogaster. Balasov, M., Huijbregts, R.P., Chesnokov, I. Mol. Cell. Biol. (2007) [Pubmed]
  2. Drosophila E2f2 promotes the conversion from genomic DNA replication to gene amplification in ovarian follicle cells. Cayirlioglu, P., Bonnette, P.C., Dickson, M.R., Duronio, R.J. Development (2001) [Pubmed]
  3. Differential regulation of the catalytic and accessory subunit genes of Drosophila mitochondrial DNA polymerase. Lefai, E., Fernandez-Moreno, M.A., Alahari, A., Kaguni, L.S., Garesse, R. J. Biol. Chem. (2000) [Pubmed]
  4. Linking cell-cycle dysfunction in Alzheimer's disease to a failure of synaptic plasticity. Arendt, T., Brückner, M.K. Biochim. Biophys. Acta (2007) [Pubmed]
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