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Gene Review

Dyrk2  -  Dual-specificity tyrosine phosphorylation...

Drosophila melanogaster

Synonyms: BG:DS01523.3, CG4551, DYRK, DYRK2, Dm2, ...
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High impact information on smi35A

  • This DYRK intermediate differs in residue and substrate specificity, as well as sensitivity to small-molecule inhibitors, compared with its mature counterpart [1].
  • Expression of the mnb (dyrk) protein in adult and embryonic mouse tissues [2].
  • This phosphorylation required the highly conserved DH-box (DYRK homology box) of dDYRK2, whereas the DH-box was not essential for phosphorylation by MNB [3].
  • To address this question, we used full-length dDYRK2 (Drosophila DYRK2) as bait in a yeast two-hybrid screen of a Drosophila embryo cDNA library [3].
  • This is the second such kinase described in Drosophila, but the first to be characterized at the molecular and biochemical level. dDYRK2 is an 81 kDa dual-specificity kinase that autophosphorylates on tyrosine and serine/threonine residues, but appears to phosphorylate exogenous substrates only on serine/threonine residues [4].

Biological context of smi35A


Analytical, diagnostic and therapeutic context of smi35A


  1. Activation-loop autophosphorylation is mediated by a novel transitional intermediate form of DYRKs. Lochhead, P.A., Sibbet, G., Morrice, N., Cleghon, V. Cell (2005) [Pubmed]
  2. Expression of the mnb (dyrk) protein in adult and embryonic mouse tissues. Rahmani, Z., Lopes, C., Rachidi, M., Delabar, J.M. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  3. dDYRK2 and Minibrain interact with the chromatin remodelling factors SNR1 and TRX. Kinstrie, R., Lochhead, P.A., Sibbet, G., Morrice, N., Cleghon, V. Biochem. J. (2006) [Pubmed]
  4. dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila. Lochhead, P.A., Sibbet, G., Kinstrie, R., Cleghon, T., Rylatt, M., Morrison, D.K., Cleghon, V. Biochem. J. (2003) [Pubmed]
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