High impact information on tup

• These results suggest that in the TN motoneuron context, Islet and Lim3 may specify axon target selection through the actions of IgSF call-adhesion molecules [1].
• Brk was found to repress two target genes, tailup and pannier, that exhibit different limits of expression within the dorsal ectoderm [2].
• Conversely, ectopic Zfh1 induces a subset of interneurons--all normally expressing two or more "ventral motor neuron transcription factors" (e.g. Islet, Hb9, Nkx6, Lim3)--to project laterally and exit the CNS [3].
• The Drosophila LIM-homeo domain protein Islet antagonizes pro-neural cell specification in the peripheral nervous system [4].
• We have taken several approaches to study the relationships between previously identified mutations (u-shaped, serpent, hindsight and tailup) that selectively cause germband retraction defects in homozygous embryos, and a more pleiotropically acting locus, DER/faint little ball [5].

Biological context of tup

• In the DC pro-neural cluster, Isl antagonizes Pnr activity both by dimerization with the DNA-binding domain of Pnr and via competitive inhibition of the Chip-bHLH interaction [4].

Anatomical context of tup

• Neurons induced in explants derived from diencephalic and telencephalic levels of the neural plate express the LIM homeodomain protein Islet-1, but these neurons possess distinct identities that match those of the ventral neurons normally generated in these two subdivisions of the forebrain [6].

Regulatory relationships of tup

• Moreover, Isl is coexpressed with Pnr in the posterior region of the mesothorax [4].

References