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Gene Review

tj  -  traffic jam

Drosophila melanogaster

Synonyms: CG10034, Dmaf, Dmel\CG10034, PL3, TJ, ...
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High impact information on tj

  • In tj mutant gonads, somatic cells fail to inter-mingle and properly envelop germline cells, causing an early block in germ cell differentiation [1].
  • Here we show that the gene traffic jam (tj) produces a soma-specific factor that controls gonad morphogenesis and is required for female and male fertility. tj encodes the only large Maf factor in Drosophila melanogaster, an orthologue of the atypical basic Leu zipper transcription factors c-Maf and MafB/Kreisler in vertebrates [1].
  • In adult flies, Dmaf is expressed in somatic gonadal cells surrounding developing oocytes and spermatocytes [2].
  • During embryonic development, Dmaf mRNA is detected in somatic gonadal precursor cells emerging from dorsolateral mesoderm [2].

Biological context of tj


Anatomical context of tj

  • We propose that tj is a critical modulator of the adhesive properties of somatic cells, facilitating germline-soma interactions that are essential for germ cell differentiation [1].

Other interactions of tj

  • These results suggest a specific function for Dmaf in gonadal development, including migration and differentiation of primordial germ cells [2].


  1. The large Maf factor Traffic Jam controls gonad morphogenesis in Drosophila. Li, M.A., Alls, J.D., Avancini, R.M., Koo, K., Godt, D. Nat. Cell Biol. (2003) [Pubmed]
  2. Dmaf, a novel member of Maf transcription factor family is expressed in somatic gonadal cells during embryonic development and gametogenesis in Drosophila. Kawashima, T., Nakamura, A., Yasuda, K., Kageyama, Y. Gene Expr. Patterns (2003) [Pubmed]
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