Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

tj - traffic jam

Drosophila melanogaster

Synonyms: CG10034, Dmaf, Dmel\CG10034, PL3, TJ, ...

Li, M.A. et al., Kawashima, T. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on tj

In tj mutant gonads, somatic cells fail to inter-mingle and properly envelop germline cells, causing an early block in germ cell differentiation [1].
Here we show that the gene traffic jam (tj) produces a soma-specific factor that controls gonad morphogenesis and is required for female and male fertility. tj encodes the only large Maf factor in Drosophila melanogaster, an orthologue of the atypical basic Leu zipper transcription factors c-Maf and MafB/Kreisler in vertebrates [1].
In adult flies, Dmaf is expressed in somatic gonadal cells surrounding developing oocytes and spermatocytes [2].
During embryonic development, Dmaf mRNA is detected in somatic gonadal precursor cells emerging from dorsolateral mesoderm [2].

Biological context of tj

Dmaf, a novel member of Maf transcription factor family is expressed in somatic gonadal cells during embryonic development and gametogenesis in Drosophila [2].

Anatomical context of tj

We propose that tj is a critical modulator of the adhesive properties of somatic cells, facilitating germline-soma interactions that are essential for germ cell differentiation [1].

Other interactions of tj

These results suggest a specific function for Dmaf in gonadal development, including migration and differentiation of primordial germ cells [2].

References

The large Maf factor Traffic Jam controls gonad morphogenesis in Drosophila. Li, M.A., Alls, J.D., Avancini, R.M., Koo, K., Godt, D. Nat. Cell Biol. (2003) [Pubmed]
Dmaf, a novel member of Maf transcription factor family is expressed in somatic gonadal cells during embryonic development and gametogenesis in Drosophila. Kawashima, T., Nakamura, A., Yasuda, K., Kageyama, Y. Gene Expr. Patterns (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.