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Gene Review:

Lcp3 - Larval cuticle protein 3

Drosophila melanogaster

Synonyms: CG2043, CP3, DMLCP3, DmelLcp3, Dmel\CG2043, ...

Snyder, M.P. et al., Steinemann, M. et al., Kimbrell, D.A. et al., Steinemann, M. et al.

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High impact information on Lcp3

Our results suggest that Lcp1 and Lcp3 loci on the degenerating Y chromosome of D. miranda are silenced by neighboring transposable elements [1].
The mutation abolishing the expression of CP3 was found to be a 7.3-kilobase DNA insertion located within the T-A-T-A box region of this gene, at -31 base pairs from the mRNA start site [2].
Thus, insertion of a transposable element into the putative promoter region of the CP3 gene is evidently responsible for inactivating CP3 gene expression [2].
Sequence analysis indicates that H.M.S. Beagle contains 266-base-pair direct repeats at its termini and is flanked by a duplication of 4 base pairs of target DNA sequence, T-A-T-A, in the CP3 gene insertion [2].
Since three of the Lcp alleles on the neo-Y are not expressed and Lcp3 is expressed only at a reduced level, it is suggestive to speculate that the rearrangements might be involved as cis-regulatory elements in the up-regulation of the X2-chromosomal Lcp alleles, in Drosophila an essential process for dosage compensation [3].

Biological context of Lcp3

The Beagle element appears to inactivate the LCP-3 gene by inserting into its TATA box, but also may cause the precocious expression of two other LCP genes, LCP-1 and LCP-f2, in the cluster [4].

References

How Y chromosomes become genetically inert. Steinemann, M., Steinemann, S., Lottspeich, F. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
A transposable element that splits the promoter region inactivates a Drosophila cuticle protein gene. Snyder, M.P., Kimbrell, D., Hunkapiller, M., Hill, R., Fristrom, J., Davidson, N. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
Evolution of the larval cuticle proteins coded by the secondary sex chromosome pair: X2 and neo-Y of Drosophila miranda: I. Comparison at the DNA sequence level. Steinemann, M., Steinemann, S., Pinsker, W. J. Mol. Evol. (1996) [Pubmed]
Regulation of larval cuticle protein gene expression in Drosophila melanogaster. Kimbrell, D.A., Tojo, S.J., Alexander, S., Brown, E.E., Tobin, S.L., Fristrom, J.W. Dev. Genet. (1989) [Pubmed]

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