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Gene Review:

Lcp2 - Larval cuticle protein 2

Drosophila melanogaster

Synonyms: CG8697, CP2, DmelLcp2, Dmel\CG8697, II, ...

Steinemann, M. et al., Casolaro, V. et al., Snyder, M.P. et al., Tojo, S.J. et al., Steinemann, M. et al.

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High impact information on Lcp2

We have transformed Drosophila with a hybrid gene consisting of the sgs-4 promoter sequence and the coding sequence for a variant (LCP-f2) of LCP-2 [1].
Protein and DNA sequence analyses indicate that point mutations cause two amino acid substitutions that change the electrophoretic mobility of CPf2 relative to that of CP2 [2].
Here we show that overexpression of CP2 enhances interleukin (IL)-4 promoter-driven chloramphenicol acetyltransferase expression, while repressing IL-2 promoter activity, in transiently transfected Jurkat cells [3].
The greatest difference between Lcp1 and Lcp2 is due to the occurrence of a pseudogene in D. melanogaster which is not present in D. miranda [4].

Biological context of Lcp2

A duplication including the Y allele of Lcp2 and the TRIM retrotransposon at the Lcp locus on the degenerating neo-Y chromosome of Drosophila miranda: molecular structure and mechanisms by which it may have arisen [5].

References

Polarized secretion of an ectopic protein in Drosophila salivary glands in vivo. Tojo, S.J., Germeraad, S., King, D.S., Fristrom, J.W. EMBO J. (1987) [Pubmed]
A transposable element that splits the promoter region inactivates a Drosophila cuticle protein gene. Snyder, M.P., Kimbrell, D., Hunkapiller, M., Hill, R., Fristrom, J., Davidson, N. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
Identification and characterization of a critical CP2-binding element in the human interleukin-4 promoter. Casolaro, V., Keane-Myers, A.M., Swendeman, S.L., Steindler, C., Zhong, F., Sheffery, M., Georas, S.N., Ono, S.J. J. Biol. Chem. (2000) [Pubmed]
Evolution of the larval cuticle proteins coded by the secondary sex chromosome pair: X2 and neo-Y of Drosophila miranda: I. Comparison at the DNA sequence level. Steinemann, M., Steinemann, S., Pinsker, W. J. Mol. Evol. (1996) [Pubmed]
A duplication including the Y allele of Lcp2 and the TRIM retrotransposon at the Lcp locus on the degenerating neo-Y chromosome of Drosophila miranda: molecular structure and mechanisms by which it may have arisen. Steinemann, M., Steinemann, S. Genetics (1993) [Pubmed]

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