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Gene Review

Lsp1  -  lymphocyte-specific protein 1

Rattus norvegicus

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Disease relevance of Lsp1


High impact information on Lsp1


Biological context of Lsp1


Anatomical context of Lsp1


Associations of Lsp1 with chemical compounds

  • Intracellular perfusion of Purkinje neurons with 100 microM of GDP or 2 microM of GTPgammaS, as well as strong depolarising pre-pulses (+100 mV), do not eliminate the action of Lsp-1 on P-channels indicating that down-modulation via guanine nucleotide-binding proteins (G-proteins) is not involved in the observed phenomenon [9].

Other interactions of Lsp1


Analytical, diagnostic and therapeutic context of Lsp1


  1. An unique CD4+CD8+ intestinal intraepithelial lymphocyte specific for DnaK (Escherichia coli HSP70) may be selected by intestinal microflora of rats. Kimura, Y., Sakai, T., Takeuchi, M., Matsumoto, Y., Watanabe, K., Yuuki, M., Takada, T., Yoshikai, Y. Immunobiology (1996) [Pubmed]
  2. Lymphocyte specific heterogeneity in the rat leucocyte common antigen (T200) is due to differences in polypeptide sequences near the NH2-terminus. Barclay, A.N., Jackson, D.I., Willis, A.C., Williams, A.F. EMBO J. (1987) [Pubmed]
  3. In vitro deamination of cytosine to uracil in single-stranded DNA by apolipoprotein B editing complex catalytic subunit 1 (APOBEC1). Petersen-Mahrt, S.K., Neuberger, M.S. J. Biol. Chem. (2003) [Pubmed]
  4. Stimulation of phosphorylation of Tyr394 by hydrogen peroxide reactivates biologically inactive, non-membrane-bound forms of Lck. Yurchak, L.K., Hardwick, J.S., Amrein, K., Pierno, K., Sefton, B.M. J. Biol. Chem. (1996) [Pubmed]
  5. Rat T lymphocyte-specific antigens and their cross-reactivity with mouse T cells. Ishii, Y., Koshiba, H., Yamaoka, H., Kikuchi, K. J. Immunol. (1976) [Pubmed]
  6. Regulation of the enzymatic function of the lymphocyte-specific tyrosine protein kinase p56lck by the non-catalytic SH2 and SH3 domains. Veillette, A., Caron, L., Fournel, M., Pawson, T. Oncogene (1992) [Pubmed]
  7. Site-specific immune response to implanted gliomas. Proescholdt, M.A., Merrill, M.J., Ikejiri, B., Walbridge, S., Akbasak, A., Jacobson, S., Oldfield, E.H. J. Neurosurg. (2001) [Pubmed]
  8. Effect of FTY720 on chronic cyclosporine nephropathy in rats. Kim, J.Y., Lim, S.W., Li, C., Kim, J.S., Ahn, K.O., Yang, H.J., Choi, B.S., Kim, Y.S., Kim, J., Bang, B.K., Yang, C.W. Transplantation (2005) [Pubmed]
  9. Novel spider toxin slows down the activation kinetics of P-type Ca2+ channels in Purkinje neurons of rat. Fisyunov, A., Pluzhnikov, K., Molyavka, A., Grishin, E., Lozovaya, N., Krishtal, O. Toxicology (2005) [Pubmed]
  10. Adenovirus-mediated in vivo gene transfer and expression in normal rat pancreas. Raper, S.E., DeMatteo, R.P. Pancreas (1996) [Pubmed]
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