The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

JUP  -  junction plakoglobin

Homo sapiens

Synonyms: ARVD12, CTNNG, Catenin gamma, DP3, DPIII, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of JUP


High impact information on JUP

  • In the adherens junction plakoglobin interacts with both the classical cadherin and with alpha-catenin [2].
  • We could find no evidence that the transcription promoter for JUP is methylated in tumour DNAs having LOH at 17q21 [3].
  • This was of interest since earlier studies have shown that JUP expression is altered in breast, lung and thyroid tumours as well as cell lines having LOH in chromosome 17q21 [3].
  • The plakophilin 1 (PKP1) and plakoglobin (JUP) genes map to human chromosomes 1q and 17, respectively [4].
  • In culture, the mRNA expression of JUP and DPK1, but not DSC1-3 and DSG1-3, was detected in all DPF clones tested and also in odontoblast-like cells (OB) expressing osteocalcin and dentin sialophosphoprotein mRNAs established in the differentiation medium [5].

Biological context of JUP


Anatomical context of JUP

  • Unlike wild-type (WT) DSP, the N-terminal mutants (V30M and Q90R) failed to localize to the cell membrane in desomosome-forming cell line and failed to bind to and coimmunoprecipitate JUP [6].

Other interactions of JUP

  • Sixteen of 22 PKP2 carriers and all 26 homozygous JUP carriers fulfilled the diagnostic criteria for ARVC, the youngest by the age of 13 years [1].


  1. Arrhythmogenic right ventricular cardiomyopathy caused by deletions in plakophilin-2 and plakoglobin (Naxos disease) in families from Greece and Cyprus: genotype-phenotype relations, diagnostic features and prognosis. Antoniades, L., Tsatsopoulou, A., Anastasakis, A., Syrris, P., Asimaki, A., Panagiotakos, D., Zambartas, C., Stefanadis, C., McKenna, W.J., Protonotarios, N. Eur. Heart J. (2006) [Pubmed]
  2. Plakoglobin domains that define its association with the desmosomal cadherins and the classical cadherins: identification of unique and shared domains. Wahl, J.K., Sacco, P.A., McGranahan-Sadler, T.M., Sauppé, L.M., Wheelock, M.J., Johnson, K.R. J. Cell. Sci. (1996) [Pubmed]
  3. Candidate target genes for loss of heterozygosity on human chromosome 17q21. De Marchis, L., Cropp, C., Sheng, Z.M., Bargo, S., Callahan, R., DeMarchis, L. Br. J. Cancer (2004) [Pubmed]
  4. The plakophilin 1 (PKP1) and plakoglobin (JUP) genes map to human chromosomes 1q and 17, respectively. Cowley, C.M., Simrak, D., Spurr, N.K., Arnemann, J., Buxton, R.S. Hum. Genet. (1997) [Pubmed]
  5. Intracellular distribution of desmoplakin in human odontoblasts. Sawa, Y., Kuroshima, S., Yamaoka, Y., Yoshida, S. J. Histochem. Cytochem. (2005) [Pubmed]
  6. Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy. Yang, Z., Bowles, N.E., Scherer, S.E., Taylor, M.D., Kearney, D.L., Ge, S., Nadvoretskiy, V.V., DeFreitas, G., Carabello, B., Brandon, L.I., Godsel, L.M., Green, K.J., Saffitz, J.E., Li, H., Danieli, G.A., Calkins, H., Marcus, F., Towbin, J.A. Circ. Res. (2006) [Pubmed]
WikiGenes - Universities