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Gene Review

Jup  -  junction plakoglobin

Mus musculus

Synonyms: AL022715, AW545708, Ctnng, D930025P04Rik, Desmoplakin III, ...
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Disease relevance of Jup


High impact information on Jup


Chemical compound and disease context of Jup


Biological context of Jup


Anatomical context of Jup


Associations of Jup with chemical compounds


Physical interactions of Jup


Co-localisations of Jup


Regulatory relationships of Jup

  • On the contrary, gamma-catenin was generally expressed at lower levels than beta-catenin, was not expressed in ductal cells and was only lightly stained on the lateral membranes of acinar cells [24].
  • In either situation, overexpression of plakoglobin was unable to modify the fibroblastic phenotype or to completely suppress the tumorigenic behavior of the spindle cells, but a moderate reduction in the growth rate of the tumors was induced by plakoglobin and was further enhanced by E-cadherin [25].

Other interactions of Jup


Analytical, diagnostic and therapeutic context of Jup


  1. Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice. Bierkamp, C., Schwarz, H., Huber, O., Kemler, R. Development (1999) [Pubmed]
  2. Mechanisms of plakoglobin-dependent adhesion: desmosome-specific functions in assembly and regulation by epidermal growth factor receptor. Yin, T., Getsios, S., Caldelari, R., Godsel, L.M., Kowalczyk, A.P., Müller, E.J., Green, K.J. J. Biol. Chem. (2005) [Pubmed]
  3. Embryonic heart and skin defects in mice lacking plakoglobin. Bierkamp, C., Mclaughlin, K.J., Schwarz, H., Huber, O., Kemler, R. Dev. Biol. (1996) [Pubmed]
  4. A central role for the armadillo protein plakoglobin in the autoimmune disease pemphigus vulgaris. Caldelari, R., de Bruin, A., Baumann, D., Suter, M.M., Bierkamp, C., Balmer, V., Müller, E. J. Cell Biol. (2001) [Pubmed]
  5. Age- and training-dependent development of arrhythmogenic right ventricular cardiomyopathy in heterozygous plakoglobin-deficient mice. Kirchhof, P., Fabritz, L., Zwiener, M., Witt, H., Sch??fers, M., Zellerhoff, S., Paul, M., Athai, T., Hiller, K.H., Baba, H.A., Breithardt, G., Ruiz, P., Wichter, T., Levkau, B. Circulation (2006) [Pubmed]
  6. Plakoglobin: a protein common to different kinds of intercellular adhering junctions. Cowin, P., Kapprell, H.P., Franke, W.W., Tamkun, J., Hynes, R.O. Cell (1986) [Pubmed]
  7. Plakoglobin and beta-catenin: distinct but closely related. Butz, S., Stappert, J., Weissig, H., Kemler, R. Science (1992) [Pubmed]
  8. Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis. Conacci-Sorrell, M.E., Ben-Yedidia, T., Shtutman, M., Feinstein, E., Einat, P., Ben-Ze'ev, A. Genes Dev. (2002) [Pubmed]
  9. gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin. Kolligs, F.T., Kolligs, B., Hajra, K.M., Hu, G., Tani, M., Cho, K.R., Fearon, E.R. Genes Dev. (2000) [Pubmed]
  10. Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy. Garcia-Gras, E., Lombardi, R., Giocondo, M.J., Willerson, J.T., Schneider, M.D., Khoury, D.S., Marian, A.J. J. Clin. Invest. (2006) [Pubmed]
  11. Protein phosphatase inhibitors and bone resorption: inhibition by okadaic acid and biphasic actions of calyculin-A. Goad, D.L., Meurer, E.A., Voelkel, E.F., Petrou, C.P., Tashjian, A.H. Endocrinology (1992) [Pubmed]
  12. The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties. Peifer, M., McCrea, P.D., Green, K.J., Wieschaus, E., Gumbiner, B.M. J. Cell Biol. (1992) [Pubmed]
  13. Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells. Müller-Tidow, C., Steffen, B., Cauvet, T., Tickenbrock, L., Ji, P., Diederichs, S., Sargin, B., Köhler, G., Stelljes, M., Puccetti, E., Ruthardt, M., deVos, S., Hiebert, S.W., Koeffler, H.P., Berdel, W.E., Serve, H. Mol. Cell. Biol. (2004) [Pubmed]
  14. The amino-terminal domain of desmoplakin binds to plakoglobin and clusters desmosomal cadherin-plakoglobin complexes. Kowalczyk, A.P., Bornslaeger, E.A., Borgwardt, J.E., Palka, H.L., Dhaliwal, A.S., Corcoran, C.M., Denning, M.F., Green, K.J. J. Cell Biol. (1997) [Pubmed]
  15. Rescuing desmoplakin function in extra-embryonic ectoderm reveals the importance of this protein in embryonic heart, neuroepithelium, skin and vasculature. Gallicano, G.I., Bauer, C., Fuchs, E. Development (2001) [Pubmed]
  16. Tyrosine phosphorylation and src family kinases control keratinocyte cell-cell adhesion. Calautti, E., Cabodi, S., Stein, P.L., Hatzfeld, M., Kedersha, N., Paolo Dotto, G. J. Cell Biol. (1998) [Pubmed]
  17. The human plakoglobin gene localizes on chromosome 17q21 and is subjected to loss of heterozygosity in breast and ovarian cancers. Aberle, H., Bierkamp, C., Torchard, D., Serova, O., Wagner, T., Natt, E., Wirsching, J., Heidkämper, C., Montagna, M., Lynch, H.T. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  18. Distribution of desmosomal proteins in F9 embryonal carcinoma cells and epithelial cell derivatives. Trevor, K.T., Steben, L.S. J. Cell. Sci. (1992) [Pubmed]
  19. Histone deacetylase inhibitors upregulate plakoglobin expression in bladder carcinoma cells and display antineoplastic activity in vitro and in vivo. Canes, D., Chiang, G.J., Billmeyer, B.R., Austin, C.A., Kosakowski, M., Rieger-Christ, K.M., Libertino, J.A., Summerhayes, I.C. Int. J. Cancer (2005) [Pubmed]
  20. Isoform-specific differences in the size of desmosomal cadherin/catenin complexes. Bannon, L.J., Cabrera, B.L., Stack, M.S., Green, K.J. J. Invest. Dermatol. (2001) [Pubmed]
  21. Cadherin/catenin complexes in murine epidermal keratinocytes: E-cadherin complexes containing either beta-catenin or plakoglobin contribute to stable cell-cell contacts. Lozano, E., Cano, A. Cell Adhes. Commun. (1998) [Pubmed]
  22. Cooperating pre-T-cell receptor and TCF-1-dependent signals ensure thymocyte survival. Goux, D., Coudert, J.D., Maurice, D., Scarpellino, L., Jeannet, G., Piccolo, S., Weston, K., Huelsken, J., Held, W. Blood (2005) [Pubmed]
  23. Plakoglobin is a component of the filamentous subplasmalemmal coat of lens cells. Franke, W.W., Kapprell, H.P., Cowin, P. Eur. J. Cell Biol. (1987) [Pubmed]
  24. Cellular basis and clinical implications of biological markers in salivary tissues: their topological distribution in murine submandibular gland. Actis, A.B., Lampe, P.D., Eynard, A.R. Oral Oncol. (2002) [Pubmed]
  25. Induction of mutual stabilization and retardation of tumor growth by coexpression of plakoglobin and E-cadherin in mouse skin spindle carcinoma cells. Lozano, E., Cano, A. Mol. Carcinog. (1998) [Pubmed]
  26. Plakoglobin binding by human Dsg3 (pemphigus vulgaris antigen) in keratinocytes requires the cadherin-like intracytoplasmic segment. Roh, J.Y., Stanley, J.R. J. Invest. Dermatol. (1995) [Pubmed]
  27. Localization of antigens associated with adherens junctions, desmosomes, and hemidesmosomes during murine molar morphogenesis. Fausser, J.L., Schlepp, O., Aberdam, D., Meneguzzi, G., Ruch, J.V., Lesot, H. Differentiation (1998) [Pubmed]
  28. Distinct location and prevalence of alpha-, beta-catenins and gamma-catenin/plakoglobin in developing and denervated skeletal muscle. Cifuentes-Diaz, C., Goudou, D., Mège, R.M., Velasco, E., Nicolet, M., Herrenknecht, K., Rubin, L., Rieger, F. Cell Adhes. Commun. (1998) [Pubmed]
  29. Molecular cloning and amino acid sequence of human plakoglobin, the common junctional plaque protein. Franke, W.W., Goldschmidt, M.D., Zimbelmann, R., Mueller, H.M., Schiller, D.L., Cowin, P. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  30. A specific domain in alpha-catenin mediates binding to beta-catenin or plakoglobin. Huber, O., Krohn, M., Kemler, R. J. Cell. Sci. (1997) [Pubmed]
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