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Gene Review

DSPP  -  dentin sialophosphoprotein

Homo sapiens

Synonyms: DFNA39, DGI1, DMP3, DPP, DSP, ...
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Disease relevance of DSPP


Psychiatry related information on DSPP


High impact information on DSPP

  • DSPP mutation in dentinogenesis imperfecta Shields type II [7].
  • Moreover, transcripts of DSPP previously reported to be expressed specifically in teeth are also detected in the inner ear of mice [3].
  • Dentinogenesis imperfecta 1 (DGI1, MIM 125490) is an autosomal dominant dental disease characterized by abnormal dentin production and mineralization [3].
  • In two other families affected with both DGI1 and DFNA39, however, we identified two independent nucleotide transversions in exons 2 and 3 of DSPP, respectively, that cause missense mutations of two adjacent amino-acid residues in the predicted transmembrane region of the protein [3].
  • We identified a nonsense mutation (Gln45stop) in exon 3 of the dentin sialophosphoprotein (DSPP) gene in a Chinese family with dentinogenesis imperfecta Shields type II (DGI-II), in which the affected members showed discoloration and severe attrition of their teeth, with obliterated pulp chambers [7].

Biological context of DSPP

  • During dentinogenesis, DSPP is proteolytically cleaved into smaller subunits [8].
  • In vivo, DSPP expression was associated with tooth terminal epithelial-mesenchymal interaction events, amelogenesis and dentinogenesis [9].
  • The purpose of this study was to perform refined mapping of DSPP related to these disease loci by gene content mapping, as well as to place the DSPP gene on the physical map of human chromosome 4 by sequence tagged site (STS) content mapping [10].
  • The genomic organization of human DSPP is very similar to that of mouse, containing five exons and four introns, suggesting it is a homologue of mouse dentin sialophosphoprotein (DSPP) [11].
  • Although no function has been ascribed to AG1 or DSP, they should prove to be important markers for the odontoblast phenotype [12].

Anatomical context of DSPP

  • Dentin sialophosphoprotein (DSPP) is a major secretory product of odontoblasts and is critical for proper tooth dentin formation [8].
  • In this report, we demonstrate that dentin matrix protein 1 (DMP1), which is localized in the nucleus during early differentiation of odontoblasts, is able to bind specifically with the DSPP promoter and activate its transcription [13].
  • We defined the exact DSPP cleavages that are catalyzed by proteases during crown formation by isolating DSPP-derived proteins from developing porcine molars and characterizing their N-terminal sequences and apparent size on SDS-PAGE and Western blots [8].
  • Dentin sialophosphoprotein (DSPP) and matrix extracellular phosphoglycoprotein (MEPE) were expressed in the proximal tubule and distal tubule, and proximal tubule, respectively [14].
  • The presence of DSPP has been recently established in salivary glands, indicating that its expression is not restricted to mineralized tissues [1].

Associations of DSPP with chemical compounds


Regulatory relationships of DSPP


Other interactions of DSPP


Analytical, diagnostic and therapeutic context of DSPP


  1. Expression of dentin sialophosphoprotein in human prostate cancer and its correlation with tumor aggressiveness. Chaplet, M., Waltregny, D., Detry, C., Fisher, L.W., Castronovo, V., Bellahcène, A. Int. J. Cancer (2006) [Pubmed]
  2. Post-translational modifications of sibling proteins and their roles in osteogenesis and dentinogenesis. Qin, C., Baba, O., Butler, W.T. Crit. Rev. Oral Biol. Med. (2004) [Pubmed]
  3. Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP. Xiao, S., Yu, C., Chou, X., Yuan, W., Wang, Y., Bu, L., Fu, G., Qian, M., Yang, J., Shi, Y., Hu, L., Han, B., Wang, Z., Huang, W., Liu, J., Chen, Z., Zhao, G., Kong, X. Nat. Genet. (2001) [Pubmed]
  4. Alterations in expression and in serum activity of dipeptidyl peptidase IV (DPP IV, CD26) in patients with hyporectic eating disorders. Hildebrandt, M., Rose, M., Mayr, C., Schüler, C., Reutter, W., Salama, A., Klapp, B.F. Scand. J. Immunol. (1999) [Pubmed]
  5. Chronoendocrine assessment of the risk of developing depressive disorders. Hermida, R.C., Ayala, D.E., Halberg, F. Prog. Clin. Biol. Res. (1990) [Pubmed]
  6. Generalized social phobia versus avoidant personality disorder: differences in psychopathology, personality traits, and social and occupational functioning. van Velzen, C.J., Emmelkamp, P.M., Scholing, A. Journal of anxiety disorders. (2000) [Pubmed]
  7. DSPP mutation in dentinogenesis imperfecta Shields type II. Zhang, X., Zhao, J., Li, C., Gao, S., Qiu, C., Liu, P., Wu, G., Qiang, B., Lo, W.H., Shen, Y. Nat. Genet. (2001) [Pubmed]
  8. Dentin Sialophosphoprotein Is Processed by MMP-2 and MMP-20 in Vitro and in Vivo. Yamakoshi, Y., Hu, J.C., Iwata, T., Kobayashi, K., Fukae, M., Simmer, J.P. J. Biol. Chem. (2006) [Pubmed]
  9. Investigation of osteocalcin, osteonectin, and dentin sialophosphoprotein in developing human teeth. Papagerakis, P., Berdal, A., Mesbah, M., Peuchmaur, M., Malaval, L., Nydegger, J., Simmer, J., Macdougall, M. Bone (2002) [Pubmed]
  10. Refined mapping of the human dentin sialophosphoprotein (DSPP) gene within the critical dentinogenesis imperfecta type II and dentin dysplasia type II loci. MacDougall, M. Eur. J. Oral Sci. (1998) [Pubmed]
  11. Molecular cloning of a human dentin sialophosphoprotein gene. Gu, K., Chang, S., Ritchie, H.H., Clarkson, B.H., Rutherford, R.B. Eur. J. Oral Sci. (2000) [Pubmed]
  12. The nature and functional significance of dentin extracellular matrix proteins. Butler, W.T., Ritchie, H. Int. J. Dev. Biol. (1995) [Pubmed]
  13. Dentin matrix protein 1 regulates dentin sialophosphoprotein gene transcription during early odontoblast differentiation. Narayanan, K., Gajjeraman, S., Ramachandran, A., Hao, J., George, A. J. Biol. Chem. (2006) [Pubmed]
  14. Renal expression of SIBLING proteins and their partner matrix metalloproteinases (MMPs). Ogbureke, K.U., Fisher, L.W. Kidney Int. (2005) [Pubmed]
  15. Dentin matrix proteins. Butler, W.T. Eur. J. Oral Sci. (1998) [Pubmed]
  16. The expression of dentin sialophosphoprotein gene in bone. Qin, C., Brunn, J.C., Cadena, E., Ridall, A., Tsujigiwa, H., Nagatsuka, H., Nagai, N., Butler, W.T. J. Dent. Res. (2002) [Pubmed]
  17. Acceleration effect of human recombinant bone morphogenetic protein-2 on differentiation of human pulp cells into odontoblasts. Saito, T., Ogawa, M., Hata, Y., Bessho, K. Journal of endodontics. (2004) [Pubmed]
  18. A novel splice acceptor mutation in the DSPP gene causing dentinogenesis imperfecta type II. Kim, J.W., Nam, S.H., Jang, K.T., Lee, S.H., Kim, C.C., Hahn, S.H., Hu, J.C., Simmer, J.P. Hum. Genet. (2004) [Pubmed]
  19. A substractive PCR-based cDNA library from human odontoblast cells: identification of novel genes expressed in tooth forming cells. Buchaille, R., Couble, M.L., Magloire, H., Bleicher, F. Matrix Biol. (2000) [Pubmed]
  20. Cluster analysis and gene expression profiles: A cDNA microarray system-based comparison between human dental pulp stem cells (hDPSCs) and human mesenchymal stem cells (hMSCs) for tissue engineering cell therapy. Yamada, Y., Fujimoto, A., Ito, A., Yoshimi, R., Ueda, M. Biomaterials (2006) [Pubmed]
  21. Heat shock induces the synthesis of the inflammatory mediator leukotriene B4 in human pulp cells. Eberhard, J., Zahl, A., Dommisch, H., Winter, J., Acil, Y., Jepsen, S. International endodontic journal. (2005) [Pubmed]
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