Gene Review:
birc5a - baculoviral IAP repeat containing 5a
Danio rerio
Synonyms:
SO:0000704, bir5a, survivin
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High impact information on birc5a
- We conclude that Su1 ubiquitous gain of function leads directly or indirectly to an increase in blood vessels size via the proliferation of endothelial cells [1].
- Transgenic expression of Su1 leads to an enlargement of tadpole's blood vessels with an increase in the number of endothelial cells [1].
- Survivin is a member of the inhibitor of apoptosis proteins (IAP) family [1].
- It does not seem to rely on the antiapoptotic activity of Su1 as it is not observed in tadpoles overexpressing other antiapoptotic factors such as XIAP or BclXL [1].
- In mammals, Survivin is not detected in most adult tissues except in endothelial cells of newly formed capillaries and large blood vessels [1].
Biological context of birc5a
- Contrary to other members that directly interact with caspases and inhibit apoptosis, Survivin is believed to have both antiapoptotic and proliferative functions [1].
- We show that the genomes of X. laevis, X. tropicalis, Zebrafish, fugu pufferfish, and rainbow trout encode two different Survivin genes (Su1 and Su2), contrary to mammalian genomes, which encode a single one [1].
References
- Survivin increased vascular development during Xenopus ontogenesis. Du Pasquier, D., Phung, A.C., Ymlahi-Ouazzani, Q., Sinzelle, L., Ballagny, C., Bronchain, O., Du Pasquier, L., Mazabraud, A. Differentiation (2006) [Pubmed]
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