Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

atpA - ATP synthase CF1 alpha chain

Nicotiana sylvestris

Schmitz-Linneweber, C. et al., Håkansson, G. et al., Hirose, T. et al.

Schmitz-Linneweber, Kushnir, Babiychuk, Poltnigg, Herrmann, Maier,

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Disease relevance of atpA

Even though changes in transcription patterns, which correlated with male sterility, were detected for three of the probes (atpA, orf25 and coxII), the changes were not consistent for all the male-sterile materials [1].

High impact information on atpA

Pigment deficiency in nightshade/tobacco cybrids is caused by the failure to edit the plastid ATPase alpha-subunit mRNA [2].
However, one editing site in the atpA transcript was found to take place partially at the third base of a serine codon (CUC_ to CUU_), thus not leading to an amino acid substitution [3].

Biological context of atpA

Here, we show by direct and reverse genetic approaches that the albino phenotype of a flowering plant with the nuclear genome of Atropa belladonna (deadly nightshade) and the plastome of Nicotiana tabacum (tobacco) develops as a result of a defect in RNA editing of a tobacco-specific editing site in the plastid ATPase alpha-subunit transcript [2].

References

Extensive nuclear influence on mitochondrial transcription and genome structure in male-fertile and male-sterile alloplasmic Nicotiana materials. Håkansson, G., Glimelius, K. Mol. Gen. Genet. (1991) [Pubmed]
Pigment deficiency in nightshade/tobacco cybrids is caused by the failure to edit the plastid ATPase alpha-subunit mRNA. Schmitz-Linneweber, C., Kushnir, S., Babiychuk, E., Poltnigg, P., Herrmann, R.G., Maier, R.M. Plant Cell (2005) [Pubmed]
Occurrence of silent RNA editing in chloroplasts: its species specificity and the influence of environmental and developmental conditions. Hirose, T., Fan, H., Suzuki, J.Y., Wakasugi, T., Tsudzuki, T., Kössel, H., Sugiura, M. Plant Mol. Biol. (1996) [Pubmed]

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