Disease relevance of Atropa

• The ability of Atropa belladonna L. and atropine to produce urinary retention has been studied in the rat [1].

High impact information on Atropa

• The pmt sequences resemble those from Nicotiana tabacum (85% identity) and those from tropane alkaloid plants, Atropa belladonna (80% identity) and Hyoscyamus niger (79% identity) [2].
• An Atropa belladonna hyoscyamine 6beta-hydroxylase gene is differentially expressed in the root pericycle and anthers [3].
• Alkaloids in plants and root cultures of Atropa belladonna overexpressing putrescine N-methyltransferase [4].
• In Atropa belladonna hairy roots, exogeneously added salicylic acid (SA) is converted to methyl salicylate (MSA) through the reaction, which might be catalysed by S-adenosyl-L-methionine: salicylic acid carboxyl methyltransferase (SAMT) [5].
• A packed-column supercritical fluid chromatography/atmospheric pressure chemical-ionisation mass spectrometry (pSFC-APCI/MS) method has been developed for the determination of atropine from Atropa belladonna L extracts [6].

Biological context of Atropa

• Amino acid sequences of ferredoxins from Atropa belladonna and Hyoscyamus niger: their similarities to those in other tropane-alkaloid-containing plants [7].

Associations of Atropa with chemical compounds

• Responses of transformed root culture of Atropa belladonna to salicylic acid stress [8].
• The aim of this study was to evaluate effects of low doses of Atropa belladonna L., Gelsemium sempervirens L. and Poumon histamine on stress-induced behavioral, immunological and gastric alterations [9].
• In order to investigate the production of tropane alkaloids by hairy roots of Atropa baetica, transgenic for the gene h6h encoding the enzyme hyoscyamine 6beta-hydroxylase, solvent extraction with chloroform and with dichloromethane of the metabolites present in the liquid medium and in the root tissue was compared [10].
• The complete amino acid sequences of [2Fe-2S] ferredoxin from Atropa belladonna and Hyoscyamus niger have been determined by automated Edman degradation of the entire S-carboxymethylcysteinyl proteins and of the peptides obtained by enzymatic digestion [7].

Analytical, diagnostic and therapeutic context of Atropa

• This single-blind placebo-controlled study was designed to investigate the dose-dependent vagolytic and vagotonic effects after a single oral administration of Atropa belladonna tincture (ABT, 0.1 mg/ml alkaloid concentration, atropine/scopolamine = 20:1) [11].

References