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MeSH Review

Atropa belladonna

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Disease relevance of Atropa belladonna

  • We introduced the hydroxylase gene from Hyoscyamus niger under the control of the cauliflower mosaic virus 35S promoter into hyoscyamine-rich Atropa belladonna by the use of an Agrobacterium-mediated transformation system [1].
  • The predicted structure was used to design recombinants of turnip yellow mosaic virus (TYMV) in which selected parts of its VP were replaced with homologous regions of belladonna mottle virus (BeMV) in a cDNA clone encoding the genome of TYMV [2].
  • Although combinations of belladonna, ergotamine, and phenobarbital have been used for medical treatment of menopausal symptoms since the 1960s, this is the first known case report of its association with anticonvulsant hypersensitivity syndrome [3].
  • Anticholinergic, or antimuscarinic, drugs have been used for the treatment of more or less specified gastrointestinal diseases or complaints for many centuries, first in herbal preparations (including belladonna), and in modern times as synthetic tertiary or quaternary compounds, with atropine being a pharmacological standard [4].
  • In patients for whom estrogens are contraindicated, atrophic vaginitis can be treated with local estrogens and vasomotor symptoms with sedatives such as phenobarbital and belladonna [5].

Psychiatry related information on Atropa belladonna


High impact information on Atropa belladonna


Associations of Atropa belladonna with chemical compounds


Gene context of Atropa belladonna


Analytical, diagnostic and therapeutic context of Atropa belladonna


  1. Metabolic engineering of medicinal plants: transgenic Atropa belladonna with an improved alkaloid composition. Yun, D.J., Hashimoto, T., Yamada, Y. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  2. Turnip yellow mosaic virus isolates with experimentally produced recombinant virion proteins. Hayden, C.M., Mackenzie, A.M., Skotnicki, M.L., Gibbs, A. J. Gen. Virol. (1998) [Pubmed]
  3. Anticonvulsant hypersensitivity syndrome associated with Bellamine S, a therapy for menopausal symptoms. Turner, R.B., Kim, C.C., Streams, B.N., Culpepper, K., Haynes, H.A. J. Am. Acad. Dermatol. (2004) [Pubmed]
  4. Antimuscarinic drugs. Stockbrügger, R.W. Methods and findings in experimental and clinical pharmacology. (1989) [Pubmed]
  5. Exogenous estrogens and endometrial carcinoma: review and comments for the clinician. Berger, G.S., Fowler, W.C. The Journal of reproductive medicine. (1977) [Pubmed]
  6. Learning deficits induced by 4 belladonna alkaloids are preferentially attenuated by tacrine. Pan, S.Y., Han, Y.F. Acta Pharmacol. Sin. (2000) [Pubmed]
  7. Reaction to phenylpropalamine/chlorpheniramine/belladonna compound in a women with unrecognised autonomic dysfunction. Pentel, P., Mikell, F. Lancet (1982) [Pubmed]
  8. Pigment deficiency in nightshade/tobacco cybrids is caused by the failure to edit the plastid ATPase alpha-subunit mRNA. Schmitz-Linneweber, C., Kushnir, S., Babiychuk, E., Poltnigg, P., Herrmann, R.G., Maier, R.M. Plant Cell (2005) [Pubmed]
  9. Zebrafish mutations affecting retinotectal axon pathfinding. Karlstrom, R.O., Trowe, T., Klostermann, S., Baier, H., Brand, M., Crawford, A.D., Grunewald, B., Haffter, P., Hoffmann, H., Meyer, S.U., Müller, B.K., Richter, S., van Eeden, F.J., Nüsslein-Volhard, C., Bonhoeffer, F. Development (1996) [Pubmed]
  10. Prevention of airway obstructions during sleep in infants with breath-holding spells by means of oral belladonna: a prospective double-blind crossover evaluation. Kahn, A., Rebuffat, E., Sottiaux, M., Muller, M.F., Bochner, A., Grosswasser, J. Sleep. (1991) [Pubmed]
  11. The treatment of narcotic withdrawal: a historical review. Kleber, H.D., Riordan, C.E. The Journal of clinical psychiatry. (1982) [Pubmed]
  12. An Atropa belladonna hyoscyamine 6beta-hydroxylase gene is differentially expressed in the root pericycle and anthers. Suzuki, K., Yun, D.J., Chen, X.Y., Yamada, Y., Hashimoto, T. Plant Mol. Biol. (1999) [Pubmed]
  13. Belladonna alkaloids and phenobarbital combination pharmaceuticals analysis I: High-performance liquid chromatographic determinations of hyoscyamine-atropine and scopolamine. Pennington, L.J., Schmidt, W.F. Journal of pharmaceutical sciences. (1982) [Pubmed]
  14. Alkaloids in plants and root cultures of Atropa belladonna overexpressing putrescine N-methyltransferase. Rothe, G., Hachiya, A., Yamada, Y., Hashimoto, T., Dräger, B. J. Exp. Bot. (2003) [Pubmed]
  15. Pathophysiology and treatment of hot flashes. Shanafelt, T.D., Barton, D.L., Adjei, A.A., Loprinzi, C.L. Mayo Clin. Proc. (2002) [Pubmed]
  16. Expression of Atropa belladonna putrescine N-methyltransferase gene in root pericycle. Suzuki, K., Yamada, Y., Hashimoto, T. Plant Cell Physiol. (1999) [Pubmed]
  17. The use of anti-asthmatic drugs. Do they affect sports performance? Fitch, K.D. Sports medicine (Auckland, N.Z.) (1986) [Pubmed]
  18. Use of clonidine to decrease intestinal fluid losses in patients with high-output short-bowel syndrome. McDoniel, K., Taylor, B., Huey, W., Eiden, K., Everett, S., Fleshman, J., Buchman, T.G., Alpers, D., Klein, S. JPEN. Journal of parenteral and enteral nutrition. (2004) [Pubmed]
  19. Lack of side effects from topically administered 10% phenylephrine eyedrops. A controlled study. Brown, M.M., Brown, G.C., Spaeth, G.L. Arch. Ophthalmol. (1980) [Pubmed]
  20. Salicylic acid carboxyl methyltransferase induced in hairy root cultures of Atropa belladonna after treatment with exogeneously added salicylic acid. Fukami, H., Asakura, T., Hirano, H., Abe, K., Shimomura, K., Yamakawa, T. Plant Cell Physiol. (2002) [Pubmed]
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