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Gene Review

otp  -  orthopedia

Drosophila melanogaster

Synonyms: BcDNA:RE58095, CG10036, CG2965, Dmel\CG10036, Homeobox protein orthopedia, ...
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High impact information on otp


Biological context of otp

  • Our analysis of the spatio-temporal expression pattern of otx and otp orthologs during P. vulgata embryogenesis leads to the following conclusions [5].

Anatomical context of otp


Analytical, diagnostic and therapeutic context of otp

  • A single putative OTP gene product was found in 17-week human fetal brain tissue by Western blot analysis using a novel polyclonal antibody raised against a conserved 13-amino-acid sequence at the C-terminus of the OTP protein [4].


  1. Brachyury proteins regulate target genes through modular binding sites in a cooperative fashion. Kusch, T., Storck, T., Walldorf, U., Reuter, R. Genes Dev. (2002) [Pubmed]
  2. Orthopedia, a novel homeobox-containing gene expressed in the developing CNS of both mouse and Drosophila. Simeone, A., D'Apice, M.R., Nigro, V., Casanova, J., Graziani, F., Acampora, D., Avantaggiato, V. Neuron (1994) [Pubmed]
  3. Homeobrain, a novel paired-like homeobox gene is expressed in the Drosophila brain. Walldorf, U., Kiewe, A., Wickert, M., Ronshaugen, M., McGinnis, W. Mech. Dev. (2000) [Pubmed]
  4. Identification, chromosomal assignment, and expression analysis of the human homeodomain-containing gene Orthopedia (OTP). Lin, X., State, M.W., Vaccarino, F.M., Greally, J., Hass, M., Leckman, J.F. Genomics (1999) [Pubmed]
  5. Novel and conserved roles for orthodenticle/ otx and orthopedia/ otp orthologs in the gastropod mollusc Patella vulgata. Nederbragt, A.J., te Welscher, P., van den Driesche, S., van Loon, A.E., Dictus, W.J. Dev. Genes Evol. (2002) [Pubmed]
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