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Gene Review:

otp - orthopedia

Drosophila melanogaster

Synonyms: BcDNA:RE58095, CG10036, CG2965, Dmel\CG10036, Homeobox protein orthopedia, ...

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High impact information on otp

Reporter assays and site-directed mutagenesis demonstrate that Brachyenteron binding sites confer in part additive, in part synergistic effects on otp transcription levels [1].
In Drosophila, otp first appears at gastrulation in the ectodermal proctodeum and later in the hindgut, anal plate, and along the CNS [2].
Two other homeobox genes, orthopedia and DRx are clustered in the 57B region along with homeobrain [3].
OTP was mapped to human chromosome 5q13.3 using radiation hybrid panel mapping and fluorescence in situ hybridization [4].
Human cDNA and genomic libraries were screened with probes derived from mouse Otp sequences to find the human homologue, OTP [4].

Biological context of otp

Our analysis of the spatio-temporal expression pattern of otx and otp orthologs during P. vulgata embryogenesis leads to the following conclusions [5].

Anatomical context of otp

We cloned orthologs of orthodenticle/ otx and orthopedia/ otpfrom the gastropod Patella vulgata, and designated them Pv-otx and Pv-otprespectively [5].

Analytical, diagnostic and therapeutic context of otp

A single putative OTP gene product was found in 17-week human fetal brain tissue by Western blot analysis using a novel polyclonal antibody raised against a conserved 13-amino-acid sequence at the C-terminus of the OTP protein [4].

References

Brachyury proteins regulate target genes through modular binding sites in a cooperative fashion. Kusch, T., Storck, T., Walldorf, U., Reuter, R. Genes Dev. (2002) [Pubmed]
Orthopedia, a novel homeobox-containing gene expressed in the developing CNS of both mouse and Drosophila. Simeone, A., D'Apice, M.R., Nigro, V., Casanova, J., Graziani, F., Acampora, D., Avantaggiato, V. Neuron (1994) [Pubmed]
Homeobrain, a novel paired-like homeobox gene is expressed in the Drosophila brain. Walldorf, U., Kiewe, A., Wickert, M., Ronshaugen, M., McGinnis, W. Mech. Dev. (2000) [Pubmed]
Identification, chromosomal assignment, and expression analysis of the human homeodomain-containing gene Orthopedia (OTP). Lin, X., State, M.W., Vaccarino, F.M., Greally, J., Hass, M., Leckman, J.F. Genomics (1999) [Pubmed]
Novel and conserved roles for orthodenticle/ otx and orthopedia/ otp orthologs in the gastropod mollusc Patella vulgata. Nederbragt, A.J., te Welscher, P., van den Driesche, S., van Loon, A.E., Dictus, W.J. Dev. Genes Evol. (2002) [Pubmed]

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