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Gene Review

KCNA6  -  potassium channel, voltage gated shaker...

Homo sapiens

Synonyms: HBK2, KV1.6, Kv1.6, PPP1R96, Potassium voltage-gated channel subfamily A member 6, ...
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High impact information on KCNA6

  • A human Ca++ channel gene, CACNL1A1, and three human K+ channel genes--KCNA5, KCNA6, and KCNA1--map close to D12S99, but the Ca++ channel gene is unlikely to be the site of the defect, because crossovers have been observed to occur between the disease gene and a CA-repeat marker located close to this gene [1].
  • Dinucleotide repeat polymorphisms near the KCNA6 and KCNA1 loci [2].
  • Antibodies targeted to KValpha1 subunits revealed KV1.3 and KV1.6 expression in whole bladder tissue samples and specifically in detrusor smooth muscle cells [3].
  • BACKGROUND: Dendrotoxin is a highly potent blocker of KV1.1, KV1.2, and KV1.6 potassium channels that is derived from the venom of the green mamba (Dendroaspis angusticeps) [4].
  • Analysis of a human brain voltage-gated potassium channel gene, KCNA6 (HBK2), in patients with juvenile myoclonic epilepsy [5].

Associations of KCNA6 with chemical compounds


Other interactions of KCNA6


  1. A gene for episodic ataxia/myokymia maps to chromosome 12p13. Litt, M., Kramer, P., Browne, D., Gancher, S., Brunt, E.R., Root, D., Phromchotikul, T., Dubay, C.J., Nutt, J. Am. J. Hum. Genet. (1994) [Pubmed]
  2. Dinucleotide repeat polymorphisms near the KCNA6 and KCNA1 loci. Browne, D.L., Litt, M. Hum. Mol. Genet. (1994) [Pubmed]
  3. Potassium channel KV alpha1 subunit expression and function in human detrusor muscle. Davies, A.M., Batchelor, T.J., Eardley, I., Beech, D.J. J. Urol. (2002) [Pubmed]
  4. Dendrotoxin poisoning in a neurobiochemist. Munday, S.W., Williams, S.R., Clark, R.F. J. Toxicol. Clin. Toxicol. (2003) [Pubmed]
  5. Analysis of a human brain voltage-gated potassium channel gene, KCNA6 (HBK2), in patients with juvenile myoclonic epilepsy. Rees, M., Elmslie, F., Whitehouse, W., Sundqvist, A., Gardiner, M. Neuropediatrics. (1995) [Pubmed]
  6. The mechanism of endothelium-independent relaxation induced by the wine polyphenol resveratrol in human internal mammary artery. Novakovic, A., Gojkovic-Bukarica, L., Peric, M., Nezic, D., Djukanovic, B., Markovic-Lipkovski, J., Heinle, H. J. Pharmacol. Sci. (2006) [Pubmed]
  7. Characterization of a voltage-activated K-channel gene cluster on human chromosome 12p13. Albrecht, B., Weber, K., Pongs, O. Recept. Channels (1995) [Pubmed]
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