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Kcna6  -  potassium voltage-gated channel, shaker...

Mus musculus

Synonyms: Kv1.6, MK1.6, Potassium voltage-gated channel subfamily A member 6, Voltage-gated potassium channel subunit Kv1.6
 
 
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High impact information on Kcna6

  • Using the oocyte heterologous expression system, pl14a was shown to inhibit both a K+ channel subtype (Kv1.6, IC50 = 1.59 microM) and neuronal (IC50 = 8.7 microM for alpha3beta4) and neuromuscular (IC50 = 0.54 microM for alpha1beta1 epsilondelta) subtypes of the nicotinic acetylcholine receptor (nAChR) [1].
  • The IKL remaining in -/- neurons was blocked by DTX, suggesting the underlying channels contained subunits Kv1.2 and/or Kv1.6 (also DTX-sensitive) [2].
  • Identification of the delayed rectifier potassium channel, Kv1.6, in cultured astrocytes [3].
  • Immunocytochemical staining showed double-labeling of glial fibrillary acidic protein-positive cells with antibody specific for the Kv1.6 channel [3].
  • Methylamine, but not ammonia, is hypophagic in mouse by interaction with brain Kv1.6 channel subtype [4].
 

Biological context of Kcna6

  • This study establishes the gene order cen-opt-dfw-Rho (D6Mit44)-Kcna1, Kcna5, Kcna6 on distal mouse Chr 6 and suggests that the neurological mutants opt and dfw affect two different genes, neither of which is caused by a mutation in any one of the three clustered K channels [5].
 

Analytical, diagnostic and therapeutic context of Kcna6

  • Reverse transcription-polymerase chain reaction, Western blot and immunohistochemical results indicate that a full expression in the brain of Kv1.6 is required only for the activity of MET, and confirms the different action mechanism of ammonia and MET [4].
  • A relatively high level of Kv1.6 transcript was identified by RT-PCR and then confirmed and quantitated by ribonuclease protection assays using a Kv1.6-specific riboprobe [3].

References

  1. A novel conotoxin inhibitor of Kv1.6 channel and nAChR subtypes defines a new superfamily of conotoxins. Imperial, J.S., Bansal, P.S., Alewood, P.F., Daly, N.L., Craik, D.J., Sporning, A., Terlau, H., López-Vera, E., Bandyopadhyay, P.K., Olivera, B.M. Biochemistry (2006) [Pubmed]
  2. Hyperexcitability and reduced low threshold potassium currents in auditory neurons of mice lacking the channel subunit Kv1.1. Brew, H.M., Hallows, J.L., Tempel, B.L. J. Physiol. (Lond.) (2003) [Pubmed]
  3. Identification of the delayed rectifier potassium channel, Kv1.6, in cultured astrocytes. Smart, S.L., Bosma, M.M., Tempel, B.L. Glia (1997) [Pubmed]
  4. Methylamine, but not ammonia, is hypophagic in mouse by interaction with brain Kv1.6 channel subtype. Pirisino, R., Ghelardini, C., Pacini, A., Galeotti, N., Raimondi, L. Br. J. Pharmacol. (2004) [Pubmed]
  5. Molecular genetic analysis of distal mouse chromosome 6 defines gene order and positions of the deafwaddler and opisthotonos mutations. Street, V.A., Robinson, L.C., Erford, S.K., Tempel, B.L. Genomics (1995) [Pubmed]
 
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