Gene Review:
CACNA1C - calcium channel, voltage-dependent, L type...
Homo sapiens
Synonyms:
CACH2, CACN2, CACNL1A1, CCHL1A1, CaV1.2, ...
Bremer,
Man,
Kask,
Diamond,
Antzelevitch,
Pollevick,
Cordeiro,
Casis,
Sanguinetti,
Aizawa,
Guerchicoff,
Pfeiffer,
Oliva,
Wollnik,
Gelber,
Bonaros,
Burashnikov,
Wu,
Sargent,
Schickel,
Oberheiden,
Bhatia,
Hsu,
Haïssaguerre,
Schimpf,
Borggrefe,
Wolpert,
Splawski,
Timothy,
Decher,
Kumar,
Sachse,
Beggs,
Sanguinetti,
Keating,
- CACNA1C polymorphisms are associated with the efficacy of calcium channel blockers in the treatment of hypertension. Bremer, T., Man, A., Kask, K., Diamond, C. Pharmacogenomics (2006)
- Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase. Fritz, T.A., Tondi, D., Finer-Moore, J.S., Costi, M.P., Stroud, R.M. Chem. Biol. (2001)
- Retroviral expression of Escherichia coli thymidylate synthase cDNA confers high-level antifolate resistance to hematopoietic cells. Shaw, D., Berger, F.G., Spencer, H.T. Hum. Gene Ther. (2001)
- Subacute sclerosing panencephalitis and progressive multiple sclerosis: T cell subsets in blood and CSF. Członkowska, A., Korlak, J., Iwińska, B. Neurology (1986)
- Hereditary agoraphobia and obsessive-compulsive behaviour in relatives of patients with Gilles de la Tourette's syndrome. Comings, D.E., Comings, B.G. The British journal of psychiatry : the journal of mental science. (1987)
- Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4. Chang, C.C., Ciubotariu, R., Manavalan, J.S., Yuan, J., Colovai, A.I., Piazza, F., Lederman, S., Colonna, M., Cortesini, R., Dalla-Favera, R., Suciu-Foca, N. Nat. Immunol. (2002)
- Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices. Erxleben, C., Liao, Y., Gentile, S., Chin, D., Gomez-Alegria, C., Mori, Y., Birnbaumer, L., Armstrong, D.L. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations. Splawski, I., Timothy, K.W., Decher, N., Kumar, P., Sachse, F.B., Beggs, A.H., Sanguinetti, M.C., Keating, M.T. Proc. Natl. Acad. Sci. U.S.A. (2005)
- A gene for episodic ataxia/myokymia maps to chromosome 12p13. Litt, M., Kramer, P., Browne, D., Gancher, S., Brunt, E.R., Root, D., Phromchotikul, T., Dubay, C.J., Nutt, J. Am. J. Hum. Genet. (1994)
- Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition. Costi, P.M., Rinaldi, M., Tondi, D., Pecorari, P., Barlocco, D., Ghelli, S., Stroud, R.M., Santi, D.V., Stout, T.J., Musiu, C., Marangiu, E.M., Pani, A., Congiu, D., Loi, G.A., La Colla, P. J. Med. Chem. (1999)
- Quantitation of thymidylate synthase in human tumors using an ultrasensitive enzyme-linked immunoassay. Johnston, P.G., Drake, J.C., Steinberg, S.M., Allegra, C.J. Biochem. Pharmacol. (1993)
- The effects of indomethacin administration during pregnancy on women's and newborns' T-suppressor lymphocyte activity and on HLA class II expression by newborns' leukocytes. Durandy, A., Brami, C., Griscelli, C. American journal of reproductive immunology and microbiology : AJRIM. (1985)
- Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death. Antzelevitch, C., Pollevick, G.D., Cordeiro, J.M., Casis, O., Sanguinetti, M.C., Aizawa, Y., Guerchicoff, A., Pfeiffer, R., Oliva, A., Wollnik, B., Gelber, P., Bonaros, E.P., Burashnikov, E., Wu, Y., Sargent, J.D., Schickel, S., Oberheiden, R., Bhatia, A., Hsu, L.F., Haïssaguerre, M., Schimpf, R., Borggrefe, M., Wolpert, C. Circulation (2007)
- Assignment of the human gene for the alpha 1 subunit of the cardiac DHP-sensitive Ca2+ channel (CCHL1A1) to chromosome 12p12-pter. Powers, P.A., Gregg, R.G., Lalley, P.A., Liao, M., Hogan, K. Genomics (1991)
- Genomic structure of human L-type Ca2+ channel. Soldatov, N.M. Genomics (1994)
- The structures of the human calcium channel alpha 1 subunit (CACNL1A2) and beta subunit (CACNLB3) genes. Yamada, Y., Masuda, K., Li, Q., Ihara, Y., Kubota, A., Miura, T., Nakamura, K., Fujii, Y., Seino, S., Seino, Y. Genomics (1995)
- Mapping of a human brain voltage-gated calcium channel to human chromosome 12p13-pter. Sun, W., McPherson, J.D., Hoang, D.Q., Wasmuth, J.J., Evans, G.A., Montal, M. Genomics (1992)
- Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase. Chu, E., Koeller, D.M., Casey, J.L., Drake, J.C., Chabner, B.A., Elwood, P.C., Zinn, S., Allegra, C.J. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Sequestration of RNA in Alzheimer's disease neurofibrillary tangles and senile plaques. Ginsberg, S.D., Crino, P.B., Lee, V.M., Eberwine, J.H., Trojanowski, J.Q. Ann. Neurol. (1997)
- Role of prostaglandin E2 in the induction of nonspecific T lymphocyte suppressor activity. Fischer, A., Durandy, A., Griscelli, C. J. Immunol. (1981)
- Stable molecular transformation of Toxoplasma gondii: a selectable dihydrofolate reductase-thymidylate synthase marker based on drug-resistance mutations in malaria. Donald, R.G., Roos, D.S. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Phosphorylation of serine 1928 in the distal C-terminal domain of cardiac CaV1.2 channels during beta1-adrenergic regulation. Hulme, J.T., Westenbroek, R.E., Scheuer, T., Catterall, W.A. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Double targeted gene replacement for creating null mutants. Cruz, A., Coburn, C.M., Beverley, S.M. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Mechanism of spontaneous excitability in human embryonic stem cell derived cardiomyocytes. Satin, J., Kehat, I., Caspi, O., Huber, I., Arbel, G., Itzhaki, I., Magyar, J., Schroder, E.A., Perlman, I., Gepstein, L. J. Physiol. (Lond.) (2004)
- Subcellular distribution of L-type Ca2+ channels responsible for plateau potentials in motoneurons from the lumbar spinal cord of the turtle. Simon, M., Perrier, J.F., Hounsgaard, J. Eur. J. Neurosci. (2003)
- 5-fluorouracil-mediated thymidylate synthase induction in malignant and nonmalignant human cells. Parr, A.L., Drake, J.C., Gress, R.E., Schwartz, G., Steinberg, S.M., Allegra, C.J. Biochem. Pharmacol. (1998)