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Gene Review

Ssl  -  Suppressor of Stellate-like

Drosophila melanogaster

Synonyms: CG13591, CK2betates, CKIIb1, DmCK2betates, Dmel\CG13591, ...
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High impact information on Ssl

  • We present evidence that SSL was derived from the genuine betaCK2 gene by reverse transcription [1].
  • Acquisition and amplification of a testis-expressed autosomal gene, SSL, by the Drosophila Y chromosome [1].
  • This event resulted in the loss of the first three introns in the coding region of the SSL ancestor gene [1].
  • SSL maps within region 60D1-2 of D. melanogaster and D. simulans polytene chromosomes [1].
  • The following peculiarities of molecular divergence of the Su(Ste) and betaCK2tes genes are revealed: damages of the autophosphorylation site; usage of an alternative splicing site instead of a damaged one; conservation of the zinc finger domain in spite of local ORF alterations [2].

Biological context of Ssl


Other interactions of Ssl

  • A two-hybrid screen of a Drosophila embryo library using CKIIalpha as bait has resulted in the isolation of multiple cDNAs encoding SSL, a CKIIbeta-like polypeptide [3].

Analytical, diagnostic and therapeutic context of Ssl

  • We have used real-time RT-PCR to assess developmental expression, and find that CKIIbeta is robust and ubiquitous, whereas SSL is restricted to males (third-instar-larvae, pupae, and adults), but is nondetectable in females of the corresponding stages [3].


  1. Acquisition and amplification of a testis-expressed autosomal gene, SSL, by the Drosophila Y chromosome. Kalmykova, A.I., Shevelyov, Y.Y., Dobritsa, A.A., Gvozdev, V.A. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. The Su(Ste) repeat in the Y chromosome and betaCK2tes gene encode predicted isoforms of regulatory beta-subunit of protein kinase CK2 in Drosophila melanogaster. Kalmykova, A.I., Dobritsa, A.A., Gvozdev, V.A. FEBS Lett. (1997) [Pubmed]
  3. The Drosophila SSL gene is expressed in larvae, pupae, and adults, exhibits sexual dimorphism, and mimics properties of the beta subunit of casein kinase II. Karandikar, U., Anderson, S., Mason, N., Trott, R.L., Bishop, C.P., Bidwai, A.P. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  4. The beta CK2tes gene encodes the tissue-specific regulatory subunit of casein kinase 2 in Drosophila melanogaster. Kalmykova, A.I., Dobritsa, A.A., Gvozdev, V.A. Biochemistry Mosc. (1997) [Pubmed]
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