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Gene Review:

icaA - N-glycosyltransferase

Staphylococcus aureus RF122

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Disease relevance of icaA

All Staphylococcus aureus prosthetic joint infection isolates (n = 55) were icaA positive [1].
To assess the clinical impact of PIA production, isolates from 15 prospectively identified cases of S. aureus bacteremia in patients with prosthetic joints (8 infected, 7 uninfected) were characterized for biofilm production, hemagglutination, and the presence of a 419-bp amplification product within icaA [2].
The objectives of the study were to examine in vitro slime production, biofilm formation, and the presence of the ica gene locus and icaA and icaD genes in S. aureus isolates from bovine mastitis [3].

High impact information on icaA

Purified SarA protein showed high-affinity binding to the icaA promoter region by electrophoretic mobility shift assays [4].
The presence of icaA in a coagulase-negative staphylococcal isolate associated with an arthroplasty is not a useful diagnostic indicator of pathogenicity [1].
In the operon, icaA encodes for N-acetylglutaminyltransferase, the enzyme for polysaccharide synthesis [5].
The presence of icaA and icaD was not correlated with slime production on CRA [6].

References

icaA is not a useful diagnostic marker for prosthetic joint infection. Frank, K.L., Hanssen, A.D., Patel, R. J. Clin. Microbiol. (2004) [Pubmed]
The intercellular adhesin locus ica is present in clinical isolates of Staphylococcus aureus from bacteremic patients with infected and uninfected prosthetic joints. Fowler, V.G., Fey, P.D., Reller, L.B., Chamis, A.L., Corey, G.R., Rupp, M.E. Med. Microbiol. Immunol. (Berl.) (2001) [Pubmed]
Phenotypic and genotypic characterization of bovine mastitis isolates of Staphylococcus aureus for biofilm formation. Vasudevan, P., Nair, M.K., Annamalai, T., Venkitanarayanan, K.S. Vet. Microbiol. (2003) [Pubmed]
SarA is an essential positive regulator of Staphylococcus epidermidis biofilm development. Tormo, M.A., Martí, M., Valle, J., Manna, A.C., Cheung, A.L., Lasa, I., Penadés, J.R. J. Bacteriol. (2005) [Pubmed]
A rapid PCR method for the detection of slime-producing strains of Staphylococcus epidermidis and S. aureus in periprosthesis infections. Arciola, C.R., Collamati, S., Donati, E., Montanaro, L. Diagn. Mol. Pathol. (2001) [Pubmed]
Genotypic and phenotypic screening of high and low virulence Staphylococcus aureus isolates from rabbits for biofilm formation and MSCRAMMs. Vancraeynest, D., Hermans, K., Haesebrouck, F. Vet. Microbiol. (2004) [Pubmed]

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