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Gene Review

recA  -  recombinase A

Staphylococcus aureus RF122

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Disease relevance of recA


High impact information on recA

  • Steady-state levels of recA and fnbB, but not fnbA, mRNA were co-coordinately increased >3-fold in CPX-exposed strain RA1 [3].
  • Whereas agr and sarA mutants of RA1 exposed to CPX still displayed increased adhesion to fibronectin, the CPX-triggered response was abolished in the uvs-568 recA mutant, but was restored following complementation with wild type recA [3].
  • We conclude that activation of recA and derepression of lexA-regulated genes by CPX may represent a response to drug-induced damage that results in a novel induction of a virulence factor leading to increased bacterial tissue adherence [3].
  • It is readily transferred to a recA recipient, and it always inserts into a unique chromosomal copy of the 17 nucleotide sequence in the same orientation [4].
  • Mutations were also obtained in recA and lsp (encoding the S. aureus prolipoprotein signal peptidase) [5].

Biological context of recA

  • To identify candidate regulatory pathway(s) linking drug exposure to up-regulation of fnbB, we disrupted the global response regulators agr, sarA, and recA in the highly quinolone-resistant strain RA1 [3].
  • Although these phenotypes were tentatively attributed to mutations within the S. aureus recA gene, experimental evidence to confirm this has never been reported [2].

Analytical, diagnostic and therapeutic context of recA


  1. Ciprofloxacin and trimethoprim cause phage induction and virulence modulation in Staphylococcus aureus. Goerke, C., Köller, J., Wolz, C. Antimicrob. Agents Chemother. (2006) [Pubmed]
  2. A genetic and molecular characterization of the recA gene from Staphylococcus aureus. Bayles, K.W., Brunskill, E.W., Iandolo, J.J., Hruska, L.L., Huang, S., Pattee, P.A., Smiley, B.K., Yasbin, R.E. Gene (1994) [Pubmed]
  3. A recA-LexA-dependent pathway mediates ciprofloxacin-induced fibronectin binding in Staphylococcus aureus. Bisognano, C., Kelley, W.L., Estoppey, T., Francois, P., Schrenzel, J., Li, D., Lew, D.P., Hooper, D.C., Cheung, A.L., Vaudaux, P. J. Biol. Chem. (2004) [Pubmed]
  4. The gene for toxic shock toxin is carried by a family of mobile pathogenicity islands in Staphylococcus aureus. Lindsay, J.A., Ruzin, A., Ross, H.F., Kurepina, N., Novick, R.P. Mol. Microbiol. (1998) [Pubmed]
  5. Identification of Staphylococcus aureus virulence genes in a murine model of bacteraemia using signature-tagged mutagenesis. Mei, J.M., Nourbakhsh, F., Ford, C.W., Holden, D.W. Mol. Microbiol. (1997) [Pubmed]
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