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Gene Review

Glut1  -  Glucose transporter 1

Drosophila melanogaster

Synonyms: 0074/12, CG1086, CG13908, CG43946, DmGLUT1, ...
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Disease relevance of Glut1

  • MATERIALS AND METHODS: Immunohistochemical expression of Glut-1 was examined in surgically resected tissues from 95 patients with esophageal squamous cell carcinoma [1].
  • RESULTS: Of the 95 esophageal carcinomas, 91 (95.8%) had some Glut-1 immunostaining in the membranes of the cancer cells [1].
  • Comparison of Glut-1 expression and clinicopathological characteristics in the 95 patients with esophageal cancer revealed significant associations between Glut-1 expression and tumor status (p < 0.001), lymph node status (p < 0.05), metastatic status (p < 0.01), and pathological stage (p < 0.001) [1].

High impact information on Glut1


Associations of Glut1 with chemical compounds

  • Here we report the results of analyses of functional sites and secondary structures of the proposed proteins and conclude that the Dmglut1 and Ceglut1 genes encode functional glucose transporters [4].


  1. Glut-1 glucose transporter expression in esophageal squamous cell carcinoma is associated with tumor aggressiveness. Kato, H., Takita, J., Miyazaki, T., Nakajima, M., Fukai, Y., Masuda, N., Fukuchi, M., Manda, R., Ojima, H., Tsukada, K., Kuwano, H. Anticancer Res. (2002) [Pubmed]
  2. Phenotypic plasticity and experimental evolution. Garland, T., Kelly, S.A. J. Exp. Biol. (2006) [Pubmed]
  3. Genetic analyses of essential genes in cytological region 61D1-2 to 61F1-2 of Drosophila melanogaster. Saito, M., Awasaki, T., Hama, C. Mol. Genet. Genomics (2002) [Pubmed]
  4. The Drosophila glucose transporter gene: cDNA sequence, phylogenetic comparisons, analysis of functional sites and secondary structures. Escher, S.A., Rasmuson-Lestander, A. Hereditas (1999) [Pubmed]
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