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Gene Review

Slc2a3  -  solute carrier family 2 (facilitated...

Rattus norvegicus

Synonyms: GLUT-3, Glucose transporter type 3, brain, Glut-3, Glut3, Solute carrier family 2, facilitated glucose transporter member 3
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Disease relevance of Slc2a3


Psychiatry related information on Slc2a3

  • After 3 days of water deprivation, the following parameters were measured in rats: (i) brain water content (apparent diffusion coefficient); (ii) local cerebral glucose utilization (LCGU) ([14C]deoxyglucose method) and (iii) densities of glucose transporters Glut1 and Glut3 (immunoautoradiography) [6].

High impact information on Slc2a3


Chemical compound and disease context of Slc2a3


Biological context of Slc2a3


Anatomical context of Slc2a3


Associations of Slc2a3 with chemical compounds

  • Increase of glucose transporter densities (Glut1 and Glut3) during chronic administration of nicotine in rat brain [15].
  • To determine whether the increased density of Glut3 is related to a change in glucose metabolism, the local cerebral metabolic rate of glucose (lCMR(glc)) was quantified by the 2-deoxyglucose method [3].
  • We suggest that those regional effects are explained, at least for a part, by the fact that central isoform glucose transporters (Glut1 and Glut3) are known to be more sensitive to pentobarbital than peripheral isoforms [16].

Regulatory relationships of Slc2a3

  • Glut 3 mRNA levels in STZ-treated and control fetal brain were equivalent and significantly less than levels of Glut 1 [9].

Other interactions of Slc2a3

  • To clarify factors inducing heterogeneous 18F-FDG distribution, we determined the intratumoral distribution of 18F-FDG by autoradiography (ARG) and compared it with the regional expression levels of glucose transporters Glut-1 and Glut-3 and hexokinase-II (HK-II) in a rat model of malignant tumor [2].

Analytical, diagnostic and therapeutic context of Slc2a3

  • Free-floating sections of fixed-frozen hippocampi were processed for quantitative immunohistochemistry of Glut3 [13].
  • This study is realised in rats by quantification of whole brain Glut3 and Glut4 mRNA in 14- and 19-day-old embryos (E14, E19), newborn (P0) and 7 postnatal-day-old rats (P7) by using reverse transcription-polymerase chain reaction (RT-PCR) method [10].


  1. Increased expression of neuronal glucose transporter 3 but not glial glucose transporter 1 following severe diffuse traumatic brain injury in rats. Hamlin, G.P., Cernak, I., Wixey, J.A., Vink, R. J. Neurotrauma (2001) [Pubmed]
  2. Biologic correlates of intratumoral heterogeneity in 18F-FDG distribution with regional expression of glucose transporters and hexokinase-II in experimental tumor. Zhao, S., Kuge, Y., Mochizuki, T., Takahashi, T., Nakada, K., Sato, M., Takei, T., Tamaki, N. J. Nucl. Med. (2005) [Pubmed]
  3. Increase in glucose transporter densities of Glut3 and decrease of glucose utilization in rat brain after one week of hypoglycemia. Duelli, R., Staudt, R., Duembgen, L., Kuschinsky, W. Brain Res. (1999) [Pubmed]
  4. Degenerative changes in spermatogonia are associated with loss of glucose transporter (Glut 3) in abdominal testis of surgically induced unilateral cryptorchidism in rats. Farooqui, S.M., Al-Bagdadi, F., O'Donnell, J.M., Stout, R. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  5. Intra-uterine growth restriction differentially regulates perinatal brain and skeletal muscle glucose transporters. Sadiq, H.F., Das, U.G., Tracy, T.F., Devaskar, S.U. Brain Res. (1999) [Pubmed]
  6. Brain water content, glucose transporter densities and glucose utilization after 3 days of water deprivation in the rat. Duelli, R., Maurer, M.H., Heiland, S., Elste, V., Kuschinsky, W. Neurosci. Lett. (1999) [Pubmed]
  7. The midcycle increase in ovarian glucose uptake is associated with enhanced expression of glucose transporter 3. Possible role for interleukin-1, a putative intermediary in the ovulatory process. Kol, S., Ben-Shlomo, I., Ruutiainen, K., Ando, M., Davies-Hill, T.M., Rohan, R.M., Simpson, I.A., Adashi, E.Y. J. Clin. Invest. (1997) [Pubmed]
  8. Glucose transporter Glut3 is targeted to secretory vesicles in neurons and PC12 cells. Thoidis, G., Kupriyanova, T., Cunningham, J.M., Chen, P., Cadel, S., Foulon, T., Cohen, P., Fine, R.E., Kandror, K.V. J. Biol. Chem. (1999) [Pubmed]
  9. The effects of severe maternal diabetes on glucose transport in the fetal rat. Atkins, V., Flozak, A.S., Ogata, E.S., Simmons, R.A. Endocrinology (1994) [Pubmed]
  10. Effects of gestational hypoxia on mRNA levels of Glut3 and Glut4 transporters, hypoxia inducible factor-1 and thyroid hormone receptors in developing rat brain. Royer, C., Lachuer, J., Crouzoulon, G., Roux, J., Peyronnet, J., Mamet, J., Pequignot, J., Dalmaz, Y. Brain Res. (2000) [Pubmed]
  11. Ethanol-induced decrease of the expression of glucose transport protein (Glut3) in the central nervous system as a predisposing condition to apoptosis: the effect of age. Fattoretti, P., Bertoni-Freddari, C., Casoli, T., Di Stefano, G., Giorgetti, G., Solazzi, M. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
  12. Effect of streptozotocin-induced maternal diabetes on fetal rat brain glucose transporters. Schroeder, R.E., Rajakumar, P.A., Devaskar, S.U. Pediatr. Res. (1997) [Pubmed]
  13. Quantitative immunohistochemistry of glucose transport protein (Glut3) expression in the rat hippocampus during aging. Fattoretti, P., Bertoni-Freddari, C., Di Stefano, G., Casoli, T., Gracciotti, N., Solazzi, M., Pompei, P. J. Histochem. Cytochem. (2001) [Pubmed]
  14. Glut1 and glut3 expression, but not capillary density, is increased by cobalt chloride in rat cerebrum and retina. Badr, G.A., Zhang, J.Z., Tang, J., Kern, T.S., Ismail-Beigi, F. Brain Res. Mol. Brain Res. (1999) [Pubmed]
  15. Increase of glucose transporter densities (Glut1 and Glut3) during chronic administration of nicotine in rat brain. Duelli, R., Staudt, R., Grünwald, F., Kuschinsky, W. Brain Res. (1998) [Pubmed]
  16. Effects of hypothermic deep-anaesthesia on energy metabolism at brain and peripheral levels: a multi-probe microdialysis study in free-moving rat. Lonjon, M., Risso, J.J., Palmier, B., Negrin, J., Darbin, O. Neurosci. Lett. (2001) [Pubmed]
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