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Gene Review

KPNB1  -  karyopherin (importin) beta 1

Homo sapiens

Synonyms: IMB1, IPO1, IPOB, Impnb, Importin subunit beta-1, ...
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Disease relevance of KPNB1

  • Strain IMB-1, an aerobic methylotrophic member of the alpha subgroup of the Proteobacteria, can grow with methyl bromide as a sole carbon and energy source [1].
  • CmuA from IMB-1 has high sequence homology to the methyltransferase CmuA from Methylobacterium chloromethanicum and Hyphomicrobium chloromethanicum and contains a C-terminal corrinoid-binding motif and an N-terminal methyltransferase motif [1].
  • 16S rRNA sequence analysis indicated that strain CC495 clusters with Rhizobium spp. in the alpha subdivision of the Proteobacteria and is closely related to strain IMB-1, a recently isolated CH(3)Br-degrading bacterium (T. L. Connell Hancock, A. M. Costello, M. E. Lidstrom, and R. S. Oremland, Appl. Environ. Microbiol. 64:2899-2905, 1998) [2].
  • Identification of methyl halide-utilizing genes in the methyl bromide-utilizing bacterial strain IMB-1 suggests a high degree of conservation of methyl halide-specific genes in gram-negative bacteria [1].

High impact information on KPNB1

  • Partial amino-acid sequencing of Xenopus importin 90 allowed us to clone and sequence its human homologue; the amino-acid sequence of importin 90 is strikingly conserved between the two species [3].
  • We discuss the relationship of importin 60 and importin 90 to other nuclear import factors [3].
  • A single cmu gene cluster was identified in IMB-1 that contained six open reading frames: cmuC, cmuA, orf146, paaE, hutI, and partial metF [1].
  • Washed cell suspensions of the facultative methylotroph strain IMB-1 grown on methyl bromide (MeBr) were able to consume methyl chloride (MeCl) and methyl iodide (MeI) as well as MeBr [4].
  • Addition of cell suspensions of strain IMB-1 to soils greatly accelerates the oxidation of MeBr, as does pretreatment of soils with low concentrations of methyl iodide [5].

Chemical compound and disease context of KPNB1

  • Phylogenetic analysis of its 16S rRNA gene sequence indicates that strain IMB-1 classes in the alpha subgroup of the class Proteobacteria and is closely related to members of the genus Rhizobium.The ability of strain IMB-1 to oxidize MeBr to CO2 is constitutive in cells regardless of the growth substrate [5].

Biological context of KPNB1


Associations of KPNB1 with chemical compounds


Analytical, diagnostic and therapeutic context of KPNB1

  • RESULTS: We have identified importin 90, a 90 kD second subunit that dissociates from importin 60 during affinity chromatography on nickel (II)-nitrolotriacetic acid-Sepharose, a technique that was originally used to purify importin 60 [3].
  • In an open-system bioreactor (10-L fermenter), strain IMB-1 oxidized a continuous supply of MeBr (220 /micromol L(-1) in air) [6].


  1. Identification of methyl halide-utilizing genes in the methyl bromide-utilizing bacterial strain IMB-1 suggests a high degree of conservation of methyl halide-specific genes in gram-negative bacteria. Woodall, C.A., Warner, K.L., Oremland, R.S., Murrell, J.C., McDonald, I.R. Appl. Environ. Microbiol. (2001) [Pubmed]
  2. Halomethane:bisulfide/halide ion methyltransferase, an unusual corrinoid enzyme of environmental significance isolated from an aerobic methylotroph using chloromethane as the sole carbon source. Coulter, C., Hamilton, J.T., McRoberts, W.C., Kulakov, L., Larkin, M.J., Harper, D.B. Appl. Environ. Microbiol. (1999) [Pubmed]
  3. Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope. Görlich, D., Kostka, S., Kraft, R., Dingwall, C., Laskey, R.A., Hartmann, E., Prehn, S. Curr. Biol. (1995) [Pubmed]
  4. Oxidation of methyl halides by the facultative methylotroph strain IMB-1. Schaefer, J.K., Oremland, R.S. Appl. Environ. Microbiol. (1999) [Pubmed]
  5. Strain IMB-1, a novel bacterium for the removal of methyl bromide in fumigated agricultural soils. Hancock, T.L., Costello, A.M., Lidstrom, M.E., Oremland, R.S. Appl. Environ. Microbiol. (1998) [Pubmed]
  6. Bioreactors for removing methyl bromide following contained fumigations. Miller, L.G., Baesman, S.M., Oremland, R.S. Environ. Sci. Technol. (2003) [Pubmed]
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