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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Hyphomicrobium


High impact information on Hyphomicrobium


Chemical compound and disease context of Hyphomicrobium

  • The soluble cytochromes c of methanol-grown Hyphomicrobium X. Evidence against the involvement of autoreduction in electron-acceptor functioning of cytochrome cL [10].
  • Dye-linked formaldehyde dehydrogenase from methylamine-grown Hyphomicrobium zavarzinii ZV 580, a tetramer of M(r) 210,000 with subunits of M(r) 54,000, was purified to homogeneity in five steps with 10% yield [11].
  • Trimethylamine dehydrogenases from bacterium W3A1 and Hyphomicrobium X and the dimethylamine dehydrogenase from Hyphomicrobium X were found to contain only one kind of subunit [12].
  • A model which accounts in a qualitative manner for the substrate dependence of the formation of the triplet state in the trimethylamine dehydrogenase of Hyphomicrobium X is proposed [13].
  • We report (1) the amino acid sequence of Hyphomicrobium denitrificans nitrite reductase (HdNIR), containing two type 1 Cu sites and one type 2 Cu site; (2) the expression and preparation of wild-type HdNIR and two mutants replacing the Cys ligand of each type 1 Cu with Ala; and (3) their spectroscopic and functional characterization [9].

Biological context of Hyphomicrobium


Anatomical context of Hyphomicrobium


Gene context of Hyphomicrobium

  • Phylogenetic and narG analysis of a Hyphomicrobium isolate [19].
  • This was shown to be similar to the MDH from Hyphomicrobium X in having 2 mol of prosthetic group (pyrroloquinoline quinine; PQQ) per mol of tetramer, the PQQ being predominantly in the semiquinone form [1].
  • Dichloromethane dehalogenase of Hyphomicrobium sp. strain DM2 [20].
  • Adenosine and AMP are present in the ratio of 1:36 in alkaline digests of Hyphomicrobium poly(A) tracts [21].
  • Isocitrate lyase of an obligate methylotrophic bacterium, Hyphomicrobium methylovorum GM2, was purified to homogeneity and characterized [22].

Analytical, diagnostic and therapeutic context of Hyphomicrobium


  1. Characterization of mutant forms of the quinoprotein methanol dehydrogenase lacking an essential calcium ion. Richardson, I.W., Anthony, C. Biochem. J. (1992) [Pubmed]
  2. Structural aspects of the dye-linked alcohol dehydrogenase of Rhodopseudomonas acidophila. Bamforth, C.W., Quayle, J.R. Biochem. J. (1979) [Pubmed]
  3. Synergistic degradation of linuron by a bacterial consortium and isolation of a single linuron-degrading variovorax strain. Dejonghe, W., Berteloot, E., Goris, J., Boon, N., Crul, K., Maertens, S., Höfte, M., De Vos, P., Verstraete, W., Top, E.M. Appl. Environ. Microbiol. (2003) [Pubmed]
  4. Diverse microbial communities inhabiting ferromanganese deposits in Lechuguilla and Spider Caves. Northup, D.E., Barns, S.M., Yu, L.E., Spilde, M.N., Schelble, R.T., Dano, K.E., Crossey, L.J., Connolly, C.A., Boston, P.J., Natvig, D.O., Dahm, C.N. Environ. Microbiol. (2003) [Pubmed]
  5. Dimethylsulfone as a growth substrate for novel methylotrophic species of Hyphomicrobium and Arthrobacter. Borodina, E., Kelly, D.P., Rainey, F.A., Ward-Rainey, N.L., Wood, A.P. Arch. Microbiol. (2000) [Pubmed]
  6. Crystallization and preliminary diffraction studies of hydroxypyruvate reductase (D-glycerate dehydrogenase) from Hyphomicrobium methylovorum. Goldberg, J.D., Brick, P., Yoshida, T., Mitsunaga, T., Oshiro, T., Shimao, M., Izumi, Y. J. Mol. Biol. (1992) [Pubmed]
  7. Crystal structures of cytochrome c(L) and methanol dehydrogenase from Hyphomicrobium denitrificans: structural and mechanistic insights into interactions between the two proteins. Nojiri, M., Hira, D., Yamaguchi, K., Okajima, T., Tanizawa, K., Suzuki, S. Biochemistry (2006) [Pubmed]
  8. Reaction of serine-glyoxylate aminotransferase with the alternative substrate ketomalonate indicates rate-limiting protonation of a quinonoid intermediate. Karsten, W.E., Ohshiro, T., Izumi, Y., Cook, P.F. Biochemistry (2005) [Pubmed]
  9. Characterization of two type 1 Cu sites of Hyphomicrobium denitrificans nitrite reductase: a new class of copper-containing nitrite reductases. Yamaguchi, K., Kataoka, K., Kobayashi, M., Itoh, K., Fukui, A., Suzuki, S. Biochemistry (2004) [Pubmed]
  10. The soluble cytochromes c of methanol-grown Hyphomicrobium X. Evidence against the involvement of autoreduction in electron-acceptor functioning of cytochrome cL. Dijkstra, M., Frank, J., van Wielink, J.E., Duine, J.A. Biochem. J. (1988) [Pubmed]
  11. A novel dye-linked formaldehyde dehydrogenase with some properties indicating the presence of a protein-bound redox-active quinone cofactor. Klein, C.R., Kesseler, F.P., Perrei, C., Frank, J., Duine, J.A., Schwartz, A.C. Biochem. J. (1994) [Pubmed]
  12. Identity of the subunits and the stoicheiometry of prosthetic groups in trimethylamine dehydrogenase and dimethylamine dehydrogenase. Kasprzak, A.A., Papas, E.J., Steenkamp, D.J. Biochem. J. (1983) [Pubmed]
  13. Mechanistic studies on the dehydrogenases of methylotrophic bacteria. 2. Kinetic studies on the intramolecular electron transfer in trimethylamine and dimethylamine dehydrogenase. Steenkamp, D.J., Beinert, H. Biochem. J. (1982) [Pubmed]
  14. Chloromethane-dependent expression of the cmu gene cluster of Hyphomicrobium chloromethanicum. Borodina, E., McDonald, I.R., Murrell, J.C. Appl. Environ. Microbiol. (2004) [Pubmed]
  15. Timing of swarmer cell cycle morphogenesis and macromolecular synthesis by Hyphomicrobium neptunium in synchronous culture. Wali, T.M., Hudson, G.R., Danald, D.A., Weiner, R.M. J. Bacteriol. (1980) [Pubmed]
  16. Identification of methyl halide-utilizing genes in the methyl bromide-utilizing bacterial strain IMB-1 suggests a high degree of conservation of methyl halide-specific genes in gram-negative bacteria. Woodall, C.A., Warner, K.L., Oremland, R.S., Murrell, J.C., McDonald, I.R. Appl. Environ. Microbiol. (2001) [Pubmed]
  17. Studies on the physiological significance of the lack of a pyruvate dehydrogenase complex in Hyphomicrobium sp. Harder, W., Matin, A., Attwood, M.M. J. Gen. Microbiol. (1975) [Pubmed]
  18. Serological relationships among budding, prosthecate bacteria. Powell, D.M., Roberson, B.S., Weiner, R.M. Can. J. Microbiol. (1980) [Pubmed]
  19. Phylogenetic and narG analysis of a Hyphomicrobium isolate. Tuhela, L., Robinson, J.B., Fishbain, S., Stahl, D.A., Tuovinen, O.H. Curr. Microbiol. (1997) [Pubmed]
  20. Dichloromethane dehalogenase of Hyphomicrobium sp. strain DM2. Kohler-Staub, D., Leisinger, T. J. Bacteriol. (1985) [Pubmed]
  21. Polyadenylic acid sequences in the RNA of Hyphomicrobium. Schultz, G.A., Chaconas, G., Moore, R.L. J. Bacteriol. (1978) [Pubmed]
  22. Characterization, gene cloning and expression of isocitrate lyase involved in the assimilation of one-carbon compounds in Hyphomicrobium methylovorum GM2. Tanaka, Y., Yoshida, T., Watanabe, K., Izumi, Y., Mitsunaga, T. Eur. J. Biochem. (1997) [Pubmed]
  23. Development of a species-specific gene probe for Hyphomicrobium facilis with the inverse PCR. Fesefeldt, A., Poetsch, M., Gliesche, C.G. Appl. Environ. Microbiol. (1997) [Pubmed]
  24. Molecular cloning and expression of the gene for serine hydroxymethyltransferase from an obligate methylotroph Hyphomicrobium methylovorum GM2. Miyata, A., Yoshida, T., Yamaguchi, K., Yokoyama, C., Tanabe, T., Toh, H., Mitsunaga, T., Izumi, Y. Eur. J. Biochem. (1993) [Pubmed]
  25. Immunological characterization of serine-glyoxylate aminotransferase and hydroxypyruvate reductase from a methylotrophic bacterium, Hyphomicrobium methylovorum GM2. Hagishita, T., Yoshida, T., Izumi, Y., Mitsunaga, T. FEMS Microbiol. Lett. (1996) [Pubmed]
  26. Photomicrography of nalidixic acid treated Hyphomicrobium neptunium: inhibition of bud formation and bud separation. Blackman, M.A., Weiner, R.M. Can. J. Microbiol. (1975) [Pubmed]
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