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Chemical Compound Review

Benzochloryl     1-chloro-4-[2,2,2-trichloro- 1-(4...

Synonyms: Arkotine, Estonate, Geusapon, Guesapon, Guesarol, ...
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Disease relevance of Neocidol


Psychiatry related information on Neocidol


High impact information on Neocidol


Chemical compound and disease context of Neocidol


Biological context of Neocidol


Anatomical context of Neocidol


Associations of Neocidol with other chemical compounds


Gene context of Neocidol

  • The cytochrome P450 Cyp6a2 and the diazepam-binding inhibitor gene (Dbi) were over transcribed in the two DDT-resistant genotypes when compared to the wild-type Drosophila, and this difference was significant at the most stringent statistical level, a Bonferroni correction [14].
  • Our results suggest that more than Cyp6g1 is overtranscribed in field and laboratory DDT-resistant genotypes, and the number of commonalities suggests that similar resistance mechanisms may exist between laboratory- and field-selected DDT-resistant fly lines [14].
  • DDT stimulates an AP-1 complex shift at the DNA to one favoring c-Jun/c-Fos dimers through both increasing c-Jun levels and by post-translational activation of c-Jun and c-Fos in HEK 293 and human endometrial Ishikawa cells [17].
  • The activity of catalase was increased in the PCB-fed rats but decreased after the administered of DDT [27].
  • High dose p,p'-DDT (1000 but not 500 mg/kg), which also induced convulsions, only slightly increased 5-HT1 (unsubtyped) binding sites in cortex but not in brainstem or spinal cord and had no effect on antagonist-labelled 5-HT2 sites [28].

Analytical, diagnostic and therapeutic context of Neocidol


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  18. Carcinogenicity study with technical-grade dichlorodiphenyltrichloroethane and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene in hamsters. Rossi, L., Barbieri, O., Sanguineti, M., Cabral, J.R., Bruzzi, P., Santi, L. Cancer Res. (1983) [Pubmed]
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  28. p,p'-DDT myoclonic/epileptic model: serotonin receptor binding and behavioral studies in the rat. Pranzatelli, M.R., Tailor, P.T., Pluchino, R., Gonzales, W., Simmens, S. Neurotoxicology (1994) [Pubmed]
  29. Myoclonus in the rat induced by p,p'-DDT and the role of altered monoamine function. Pratt, J.A., Rothwell, J., Jenner, P., Marsden, C.D. Neuropharmacology (1985) [Pubmed]
  30. Identification of differentially expressed genes in Tetrahymena thermophila in response to dichlorodiphenyltrichloroethane (DDT) by suppression subtractive hybridization. Miao, W., Yu, T., Orias, E., Wan, M., Fu, C. Environ. Microbiol. (2006) [Pubmed]
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